Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management
Sotiria Palimeri,* Eleni Palioura,* Evanthia Diamanti-KandarakisEndocrine Unit, Medical School University of Athens, Athens, Greece*These authors contributed equally to this workAbstract: Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2015-09-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Online Access: | http://www.dovepress.com/current-perspectives-on-the-health-risks-associated-with-the-consumpti-peer-reviewed-article-DMSO |
| _version_ | 1797936948364443648 |
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| author | Palimeri S Palioura E Diamanti-Kandarakis E |
| author_facet | Palimeri S Palioura E Diamanti-Kandarakis E |
| author_sort | Palimeri S |
| collection | DOAJ |
| description | Sotiria Palimeri,* Eleni Palioura,* Evanthia Diamanti-KandarakisEndocrine Unit, Medical School University of Athens, Athens, Greece*These authors contributed equally to this workAbstract: Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the aging process and under conditions of hyperglycemia and oxidative stress. AGEs also have an emerging exogenous origin. Cigarette smoke and diet are the two main exogenous sources of AGEs (glycotoxins). Modern Western diets are rich in AGEs which have been implicated in the pathogenesis of several metabolic and degenerative disorders. Accumulating evidence underlies the beneficial effect of the dietary restriction of AGEs not only in animal studies but also in patients with diabetic complications and metabolic diseases. This article reviews the evidence linking dietary glycotoxins to several disorders from diabetic complications and renal failure to liver dysfunction, female reproduction, eye and cognitive disorders as well as cancer. Furthermore, strategies for AGE reduction are discussed with a focus on dietary modification.Keywords: AGEs, dietary glycotoxins, dietary restriction, PCOS, MSR-1, RAGE |
| first_indexed | 2024-04-10T18:37:12Z |
| format | Article |
| id | doaj.art-314ad5bfecdc47cbaafbde09b92bf2db |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:37:12Z |
| publishDate | 2015-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-314ad5bfecdc47cbaafbde09b92bf2db2023-02-02T00:17:44ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072015-09-012015default41542623478Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary managementPalimeri SPalioura EDiamanti-Kandarakis ESotiria Palimeri,* Eleni Palioura,* Evanthia Diamanti-KandarakisEndocrine Unit, Medical School University of Athens, Athens, Greece*These authors contributed equally to this workAbstract: Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the aging process and under conditions of hyperglycemia and oxidative stress. AGEs also have an emerging exogenous origin. Cigarette smoke and diet are the two main exogenous sources of AGEs (glycotoxins). Modern Western diets are rich in AGEs which have been implicated in the pathogenesis of several metabolic and degenerative disorders. Accumulating evidence underlies the beneficial effect of the dietary restriction of AGEs not only in animal studies but also in patients with diabetic complications and metabolic diseases. This article reviews the evidence linking dietary glycotoxins to several disorders from diabetic complications and renal failure to liver dysfunction, female reproduction, eye and cognitive disorders as well as cancer. Furthermore, strategies for AGE reduction are discussed with a focus on dietary modification.Keywords: AGEs, dietary glycotoxins, dietary restriction, PCOS, MSR-1, RAGEhttp://www.dovepress.com/current-perspectives-on-the-health-risks-associated-with-the-consumpti-peer-reviewed-article-DMSO |
| spellingShingle | Palimeri S Palioura E Diamanti-Kandarakis E Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management Diabetes, Metabolic Syndrome and Obesity |
| title | Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management |
| title_full | Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management |
| title_fullStr | Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management |
| title_full_unstemmed | Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management |
| title_short | Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management |
| title_sort | current perspectives on the health risks associated with the consumption of advanced glycation end products recommendations for dietary management |
| url | http://www.dovepress.com/current-perspectives-on-the-health-risks-associated-with-the-consumpti-peer-reviewed-article-DMSO |
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