| Summary: | <p><strong>Objective</strong> To study the clinical features of cryptococcal meningitis (CM) and summarize its clinical manifestations, laboratory data, differential diagnosis and treatment, so as to discuss the treatment progress of CM. <strong>Methods</strong> Clinical data of 26 cases with CM were retrospectively analyzed, and the treatment experiences were summarized. <strong>Results</strong> All patients had headache and fever, and were positive for cerebrospinal fluid (CSF) latex agglutination test. Twenty-one patients' CSF smear were found Cryptococcus neoformans. Almost 76.92% (20/26) of patients were cured or became better after receiving combined treatment of amphotericin B, flucytosine and fluconazole. The symptoms and signs of 4 patients who received combined treatment of amphotericin B and voriconazole were greatly improved. <strong>Conclusions</strong> CM can prone to be misdiagnosed at early stage. CSF smear and fungi culture are beneficial to the diagnosis. Latex agglutination test is a quick and easy examination to reduce the misdiagnosis rate of CM. The combination of amphotericin B, flucytosine and fluconazole is effective for the treatment of CM.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.08.009</p>
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