Clinical analysis of 26 cases with cryptococcal meningitis
<p><strong>Objective</strong> To study the clinical features of cryptococcal meningitis (CM) and summarize its clinical manifestations, laboratory data, differential diagnosis and treatment, so as to discuss the treatment progress of CM. <strong>Methods</strong> Cli...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2014-08-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/1016 |
| _version_ | 1818382312975368192 |
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| author | Wei-wei HU Yu-wu ZHAO Qing-chun PAN Min XI Zheng-hao TANG Guo-qing ZANG |
| author_facet | Wei-wei HU Yu-wu ZHAO Qing-chun PAN Min XI Zheng-hao TANG Guo-qing ZANG |
| author_sort | Wei-wei HU |
| collection | DOAJ |
| description | <p><strong>Objective</strong> To study the clinical features of cryptococcal meningitis (CM) and summarize its clinical manifestations, laboratory data, differential diagnosis and treatment, so as to discuss the treatment progress of CM. <strong>Methods</strong> Clinical data of 26 cases with CM were retrospectively analyzed, and the treatment experiences were summarized. <strong>Results</strong> All patients had headache and fever, and were positive for cerebrospinal fluid (CSF) latex agglutination test. Twenty-one patients' CSF smear were found Cryptococcus neoformans. Almost 76.92% (20/26) of patients were cured or became better after receiving combined treatment of amphotericin B, flucytosine and fluconazole. The symptoms and signs of 4 patients who received combined treatment of amphotericin B and voriconazole were greatly improved. <strong>Conclusions</strong> CM can prone to be misdiagnosed at early stage. CSF smear and fungi culture are beneficial to the diagnosis. Latex agglutination test is a quick and easy examination to reduce the misdiagnosis rate of CM. The combination of amphotericin B, flucytosine and fluconazole is effective for the treatment of CM.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.08.009</p> |
| first_indexed | 2024-12-14T02:48:29Z |
| format | Article |
| id | doaj.art-314af7f7dca14919ac6c9f0fab06a0ac |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-12-14T02:48:29Z |
| publishDate | 2014-08-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-314af7f7dca14919ac6c9f0fab06a0ac2022-12-21T23:19:49ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312014-08-011486936961012Clinical analysis of 26 cases with cryptococcal meningitisWei-wei HU0Yu-wu ZHAO1Qing-chun PAN2Min XI3Zheng-hao TANG4Guo-qing ZANG5Department of Infectious Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, ChinaDepartment of Infectious Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, ChinaDepartment of Infectious Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, ChinaDepartment of Infectious Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, ChinaDepartment of Infectious Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, ChinaDepartment of Infectious Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China<p><strong>Objective</strong> To study the clinical features of cryptococcal meningitis (CM) and summarize its clinical manifestations, laboratory data, differential diagnosis and treatment, so as to discuss the treatment progress of CM. <strong>Methods</strong> Clinical data of 26 cases with CM were retrospectively analyzed, and the treatment experiences were summarized. <strong>Results</strong> All patients had headache and fever, and were positive for cerebrospinal fluid (CSF) latex agglutination test. Twenty-one patients' CSF smear were found Cryptococcus neoformans. Almost 76.92% (20/26) of patients were cured or became better after receiving combined treatment of amphotericin B, flucytosine and fluconazole. The symptoms and signs of 4 patients who received combined treatment of amphotericin B and voriconazole were greatly improved. <strong>Conclusions</strong> CM can prone to be misdiagnosed at early stage. CSF smear and fungi culture are beneficial to the diagnosis. Latex agglutination test is a quick and easy examination to reduce the misdiagnosis rate of CM. The combination of amphotericin B, flucytosine and fluconazole is effective for the treatment of CM.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.08.009</p>http://www.cjcnn.org/index.php/cjcnn/article/view/1016Meningitis, cryptococcalAmphotericin BDrug therapy, combination |
| spellingShingle | Wei-wei HU Yu-wu ZHAO Qing-chun PAN Min XI Zheng-hao TANG Guo-qing ZANG Clinical analysis of 26 cases with cryptococcal meningitis Chinese Journal of Contemporary Neurology and Neurosurgery Meningitis, cryptococcal Amphotericin B Drug therapy, combination |
| title | Clinical analysis of 26 cases with cryptococcal meningitis |
| title_full | Clinical analysis of 26 cases with cryptococcal meningitis |
| title_fullStr | Clinical analysis of 26 cases with cryptococcal meningitis |
| title_full_unstemmed | Clinical analysis of 26 cases with cryptococcal meningitis |
| title_short | Clinical analysis of 26 cases with cryptococcal meningitis |
| title_sort | clinical analysis of 26 cases with cryptococcal meningitis |
| topic | Meningitis, cryptococcal Amphotericin B Drug therapy, combination |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/1016 |
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