SLC6A3 Polymorphism Predisposes to Dopamine Overdose in Parkinson's Disease

SLC6A3 Polymorphism Predisposes to Dopamine Overdose in Parkinson's Disease

In Parkinson's disease (PD), cognitive functions mediated by brain regions innervated by ventral tegmental area (VTA) worsen with dopamine replacement therapy, whereas processes relying on regions innervated by the substantia nigra pars compacta (SNc) improve. The SLC6A3 gene encodes the dopami...

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Bibliographic Details
Main Authors: Brian D. Robertson, Abdullah S. Al Jaja, Alex A. MacDonald, Nole M. Hiebert, Ruzbeh Tamjeedi, Ken N. Seergobin, Ute I. Schwarz, Richard B. Kim, Penny A. MacDonald
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neurology
Subjects:
Parkinson's disease
polymorphism
SLC6A3
overdose
dopamine
encoding
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00693/full

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