Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology
Ischemic stroke (IS) is one of the leading causes of mortality worldwide. It is characterized by the partial or total occlusion of arteries that supply blood to the brain, leading to the death of brain cells. In recent years, natural bioactive compounds (NBCs) have shown properties that ameliorate t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/10/1376 |
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| author | Juan Carlos Gomez-Verjan Emmanuel Alejandro Zepeda-Arzate José Alberto Santiago-de-la-Cruz Edgar Antonio Estrella-Parra Nadia Alejandra Rivero-Segura |
| author_facet | Juan Carlos Gomez-Verjan Emmanuel Alejandro Zepeda-Arzate José Alberto Santiago-de-la-Cruz Edgar Antonio Estrella-Parra Nadia Alejandra Rivero-Segura |
| author_sort | Juan Carlos Gomez-Verjan |
| collection | DOAJ |
| description | Ischemic stroke (IS) is one of the leading causes of mortality worldwide. It is characterized by the partial or total occlusion of arteries that supply blood to the brain, leading to the death of brain cells. In recent years, natural bioactive compounds (NBCs) have shown properties that ameliorate the injury after IS and improve the patient’s outcome, which has proven to be a potential therapeutic strategy due to their neuroprotective effects. Hence, in the present study, we use both systems pharmacology and chemoinformatic analyses to identify which NBCs have the most potential to be used against IS in clinics. Our results identify that flavonoids and terpenoids are the most studied NBCs, and, mainly, salidrosides, ginkgolides A, B, C, and K, cordycepin, curcumin, baicalin, resveratrol, fucose, and cannabidiol, target the main pathological processes occurring in IS. However, the medicinal chemistry properties of such compounds demonstrate that only six fulfill such criteria. However, only cordycepin and salidroside possess properties as leader molecules, suggesting that these compounds may be considered in developing novel drugs against IS. |
| first_indexed | 2024-03-10T20:58:29Z |
| format | Article |
| id | doaj.art-314ca76f7f804b8d9e135dcd5a05ee69 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T20:58:29Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-314ca76f7f804b8d9e135dcd5a05ee692023-11-19T17:41:37ZengMDPI AGPharmaceuticals1424-82472023-09-011610137610.3390/ph16101376Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network PharmacologyJuan Carlos Gomez-Verjan0Emmanuel Alejandro Zepeda-Arzate1José Alberto Santiago-de-la-Cruz2Edgar Antonio Estrella-Parra3Nadia Alejandra Rivero-Segura4Dirección de Investigación, Instituto Nacional de Geriatría (INGER), Blvd. Adolfo Ruiz Cortines 2767, Mexico City 10200, MexicoDirección de Investigación, Instituto Nacional de Geriatría (INGER), Blvd. Adolfo Ruiz Cortines 2767, Mexico City 10200, MexicoDirección de Investigación, Instituto Nacional de Geriatría (INGER), Blvd. Adolfo Ruiz Cortines 2767, Mexico City 10200, MexicoLaboratorio de Fitoquímica, UBIPRO, FES-Iztacala, Unidad Nacional Autónoma de México, Av. De los Barrios No.1, Los Reyes Iztacala, Tlalnepantla 54090, MexicoDirección de Investigación, Instituto Nacional de Geriatría (INGER), Blvd. Adolfo Ruiz Cortines 2767, Mexico City 10200, MexicoIschemic stroke (IS) is one of the leading causes of mortality worldwide. It is characterized by the partial or total occlusion of arteries that supply blood to the brain, leading to the death of brain cells. In recent years, natural bioactive compounds (NBCs) have shown properties that ameliorate the injury after IS and improve the patient’s outcome, which has proven to be a potential therapeutic strategy due to their neuroprotective effects. Hence, in the present study, we use both systems pharmacology and chemoinformatic analyses to identify which NBCs have the most potential to be used against IS in clinics. Our results identify that flavonoids and terpenoids are the most studied NBCs, and, mainly, salidrosides, ginkgolides A, B, C, and K, cordycepin, curcumin, baicalin, resveratrol, fucose, and cannabidiol, target the main pathological processes occurring in IS. However, the medicinal chemistry properties of such compounds demonstrate that only six fulfill such criteria. However, only cordycepin and salidroside possess properties as leader molecules, suggesting that these compounds may be considered in developing novel drugs against IS.https://www.mdpi.com/1424-8247/16/10/1376natural bioactive compoundsnatural productsnetwork pharmacologyneuroprotectionischemic strokeflavonoids |
| spellingShingle | Juan Carlos Gomez-Verjan Emmanuel Alejandro Zepeda-Arzate José Alberto Santiago-de-la-Cruz Edgar Antonio Estrella-Parra Nadia Alejandra Rivero-Segura Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology Pharmaceuticals natural bioactive compounds natural products network pharmacology neuroprotection ischemic stroke flavonoids |
| title | Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology |
| title_full | Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology |
| title_fullStr | Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology |
| title_full_unstemmed | Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology |
| title_short | Unraveling the Neuroprotective Effect of Natural Bioactive Compounds Involved in the Modulation of Ischemic Stroke by Network Pharmacology |
| title_sort | unraveling the neuroprotective effect of natural bioactive compounds involved in the modulation of ischemic stroke by network pharmacology |
| topic | natural bioactive compounds natural products network pharmacology neuroprotection ischemic stroke flavonoids |
| url | https://www.mdpi.com/1424-8247/16/10/1376 |
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