Circadian Rhythms of Body Temperature and Locomotor Activity in Spontaneously Hypertensive Rats under Frequent Changes in Light Conditions
Changes in lighting accompany modern urbanization trends and can lead to various pathologies based on circadian disturbances. In this study, we assessed the changes in the circadian rhythm of core body temperature (Tcore) and locomotor activity of Wistar-Kyoto rats (WKY) and spontaneously hypertensi...
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MDPI AG
2024-03-01
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| Series: | Pathophysiology |
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| Online Access: | https://www.mdpi.com/1873-149X/31/1/10 |
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| author | Anna Yu. Ryabinina Anna A. Bryk Mikhail L. Blagonravov Vyacheslav A. Goryachev Andrey A. Mozhaev Vera S. Ovechkina |
| author_facet | Anna Yu. Ryabinina Anna A. Bryk Mikhail L. Blagonravov Vyacheslav A. Goryachev Andrey A. Mozhaev Vera S. Ovechkina |
| author_sort | Anna Yu. Ryabinina |
| collection | DOAJ |
| description | Changes in lighting accompany modern urbanization trends and can lead to various pathologies based on circadian disturbances. In this study, we assessed the changes in the circadian rhythm of core body temperature (Tcore) and locomotor activity of Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) following exposure to different lighting conditions: extended light phase of the day (16 h–8 h, 20 h–4 h, 24 h–0 h), light pollution, monochromatic light, and bright light therapy. The telemetry data was collected after experimental lighting conditions during periods with standard lighting (12 h of light and 12 h of darkness) and was processed using linear and cosinor analysis. The daily rhythms of rats’ parameters persisted in accordance with the standard lighting regime. Tcore changes were observed in both groups compared to the initial period: in WKY, a decrease in Tcore during the darkness and an increase during the light; in SHR, the opposite trend, with Tcore increased during the darkness and decreased during the light phase of the day. A relationship between Tcore and activity was observed with weak correlation. WKY exhibited more pronounced signs of adaptive variation and desynchronization compared to SHR, which could be associated with a wider range of functional capabilities of the organism without cardiovascular pathology. |
| first_indexed | 2024-04-24T17:55:54Z |
| format | Article |
| id | doaj.art-314d5733e7fa4edab96a803ae95c3b3e |
| institution | Directory Open Access Journal |
| issn | 1873-149X |
| language | English |
| last_indexed | 2024-04-24T17:55:54Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathophysiology |
| spelling | doaj.art-314d5733e7fa4edab96a803ae95c3b3e2024-03-27T13:59:03ZengMDPI AGPathophysiology1873-149X2024-03-0131112714610.3390/pathophysiology31010010Circadian Rhythms of Body Temperature and Locomotor Activity in Spontaneously Hypertensive Rats under Frequent Changes in Light ConditionsAnna Yu. Ryabinina0Anna A. Bryk1Mikhail L. Blagonravov2Vyacheslav A. Goryachev3Andrey A. Mozhaev4Vera S. Ovechkina5V.A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, RussiaV.A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, RussiaV.A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, RussiaV.A. Frolov Department of General Pathology and Pathological Physiology, Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya, 16/10, 117997 Moscow, RussiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya, 16/10, 117997 Moscow, RussiaChanges in lighting accompany modern urbanization trends and can lead to various pathologies based on circadian disturbances. In this study, we assessed the changes in the circadian rhythm of core body temperature (Tcore) and locomotor activity of Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) following exposure to different lighting conditions: extended light phase of the day (16 h–8 h, 20 h–4 h, 24 h–0 h), light pollution, monochromatic light, and bright light therapy. The telemetry data was collected after experimental lighting conditions during periods with standard lighting (12 h of light and 12 h of darkness) and was processed using linear and cosinor analysis. The daily rhythms of rats’ parameters persisted in accordance with the standard lighting regime. Tcore changes were observed in both groups compared to the initial period: in WKY, a decrease in Tcore during the darkness and an increase during the light; in SHR, the opposite trend, with Tcore increased during the darkness and decreased during the light phase of the day. A relationship between Tcore and activity was observed with weak correlation. WKY exhibited more pronounced signs of adaptive variation and desynchronization compared to SHR, which could be associated with a wider range of functional capabilities of the organism without cardiovascular pathology.https://www.mdpi.com/1873-149X/31/1/10core body temperaturelocomotor activityspontaneously hypertensive ratstelemetrychronobiologycosinor |
| spellingShingle | Anna Yu. Ryabinina Anna A. Bryk Mikhail L. Blagonravov Vyacheslav A. Goryachev Andrey A. Mozhaev Vera S. Ovechkina Circadian Rhythms of Body Temperature and Locomotor Activity in Spontaneously Hypertensive Rats under Frequent Changes in Light Conditions Pathophysiology core body temperature locomotor activity spontaneously hypertensive rats telemetry chronobiology cosinor |
| title | Circadian Rhythms of Body Temperature and Locomotor Activity in Spontaneously Hypertensive Rats under Frequent Changes in Light Conditions |
| title_full | Circadian Rhythms of Body Temperature and Locomotor Activity in Spontaneously Hypertensive Rats under Frequent Changes in Light Conditions |
| title_fullStr | Circadian Rhythms of Body Temperature and Locomotor Activity in Spontaneously Hypertensive Rats under Frequent Changes in Light Conditions |
| title_full_unstemmed | Circadian Rhythms of Body Temperature and Locomotor Activity in Spontaneously Hypertensive Rats under Frequent Changes in Light Conditions |
| title_short | Circadian Rhythms of Body Temperature and Locomotor Activity in Spontaneously Hypertensive Rats under Frequent Changes in Light Conditions |
| title_sort | circadian rhythms of body temperature and locomotor activity in spontaneously hypertensive rats under frequent changes in light conditions |
| topic | core body temperature locomotor activity spontaneously hypertensive rats telemetry chronobiology cosinor |
| url | https://www.mdpi.com/1873-149X/31/1/10 |
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