Subject-Specific Modeling of Femoral Torsion Influences the Prediction of Hip Loading During Gait in Asymptomatic Adults
Hip osteoarthritis may be caused by increased or abnormal intra-articular forces, which are known to be related to structural articular cartilage damage. Femoral torsional deformities have previously been correlated with hip pain and labral damage, and they may contribute to the onset of hip osteoar...
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| Format: | Article |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.679360/full |
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| author | Enrico De Pieri Enrico De Pieri Enrico De Pieri Bernd Friesenbichler Renate List Samara Monn Nicola C. Casartelli Nicola C. Casartelli Michael Leunig Stephen J. Ferguson |
| author_facet | Enrico De Pieri Enrico De Pieri Enrico De Pieri Bernd Friesenbichler Renate List Samara Monn Nicola C. Casartelli Nicola C. Casartelli Michael Leunig Stephen J. Ferguson |
| author_sort | Enrico De Pieri |
| collection | DOAJ |
| description | Hip osteoarthritis may be caused by increased or abnormal intra-articular forces, which are known to be related to structural articular cartilage damage. Femoral torsional deformities have previously been correlated with hip pain and labral damage, and they may contribute to the onset of hip osteoarthritis by exacerbating the effects of existing pathoanatomies, such as cam and pincer morphologies. A comprehensive understanding of the influence of femoral morphotypes on hip joint loading requires subject-specific morphometric and biomechanical data on the movement characteristics of individuals exhibiting varying degrees of femoral torsion. The aim of this study was to evaluate hip kinematics and kinetics as well as muscle and joint loads during gait in a group of adult subjects presenting a heterogeneous range of femoral torsion by means of personalized musculoskeletal models. Thirty-seven healthy volunteers underwent a 3D gait analysis at a self-selected walking speed. Femoral torsion was evaluated with low-dosage biplanar radiography. The collected motion capture data were used as input for an inverse dynamics analysis. Personalized musculoskeletal models were created by including femoral geometries that matched each subject’s radiographically measured femoral torsion. Correlations between femoral torsion and hip kinematics and kinetics, hip contact forces (HCFs), and muscle forces were analyzed. Within the investigated cohort, higher femoral antetorsion led to significantly higher anteromedial HCFs during gait (medial during loaded stance phase and anterior during swing phase). Most of the loads during gait are transmitted through the anterior/superolateral quadrant of the acetabulum. Correlations with hip kinematics and muscle forces were also observed. Femoral antetorsion, through altered kinematic strategies and different muscle activations and forces, may therefore lead to altered joint mechanics and pose a risk for articular damage. The method proposed in this study, which accounts for both morphological and kinematic characteristics, might help in identifying in a clinical setting patients who, as a consequence of altered femoral torsional alignment, present more severe functional impairments and altered joint mechanics and are therefore at a higher risk for cartilage damage and early onset of hip osteoarthritis. |
| first_indexed | 2024-12-18T01:57:32Z |
| format | Article |
| id | doaj.art-314f8f40eed24bc2b6d8e5599bdbbf80 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-18T01:57:32Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-314f8f40eed24bc2b6d8e5599bdbbf802022-12-21T21:24:51ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-07-01910.3389/fbioe.2021.679360679360Subject-Specific Modeling of Femoral Torsion Influences the Prediction of Hip Loading During Gait in Asymptomatic AdultsEnrico De Pieri0Enrico De Pieri1Enrico De Pieri2Bernd Friesenbichler3Renate List4Samara Monn5Nicola C. Casartelli6Nicola C. Casartelli7Michael Leunig8Stephen J. Ferguson9Laboratory for Movement Analysis, University of Basel Children’s Hospital, Basel, SwitzerlandDepartment of Biomedical Engineering, University of Basel, Basel, SwitzerlandInstitute for Biomechanics, ETH Zurich, Zürich, SwitzerlandHuman Performance Lab, Schulthess Clinic, Zürich, SwitzerlandHuman Performance Lab, Schulthess Clinic, Zürich, SwitzerlandHuman Performance Lab, Schulthess Clinic, Zürich, SwitzerlandHuman Performance Lab, Schulthess Clinic, Zürich, SwitzerlandLaboratory of Exercise and Health, ETH Zurich, Schwerzenbach, SwitzerlandDepartment of Orthopaedic Surgery, Schulthess Clinic, Zürich, SwitzerlandInstitute for Biomechanics, ETH Zurich, Zürich, SwitzerlandHip osteoarthritis may be caused by increased or abnormal intra-articular forces, which are known to be related to structural articular cartilage damage. Femoral torsional deformities have previously been correlated with hip pain and labral damage, and they may contribute to the onset of hip osteoarthritis by exacerbating the effects of existing pathoanatomies, such as cam and pincer morphologies. A comprehensive understanding of the influence of femoral morphotypes on hip joint loading requires subject-specific morphometric and biomechanical data on the movement characteristics of individuals exhibiting varying degrees of femoral torsion. The aim of this study was to evaluate hip kinematics and kinetics as well as muscle and joint loads during gait in a group of adult subjects presenting a heterogeneous range of femoral torsion by means of personalized musculoskeletal models. Thirty-seven healthy volunteers underwent a 3D gait analysis at a self-selected walking speed. Femoral torsion was evaluated with low-dosage biplanar radiography. The collected motion capture data were used as input for an inverse dynamics analysis. Personalized musculoskeletal models were created by including femoral geometries that matched each subject’s radiographically measured femoral torsion. Correlations between femoral torsion and hip kinematics and kinetics, hip contact forces (HCFs), and muscle forces were analyzed. Within the investigated cohort, higher femoral antetorsion led to significantly higher anteromedial HCFs during gait (medial during loaded stance phase and anterior during swing phase). Most of the loads during gait are transmitted through the anterior/superolateral quadrant of the acetabulum. Correlations with hip kinematics and muscle forces were also observed. Femoral antetorsion, through altered kinematic strategies and different muscle activations and forces, may therefore lead to altered joint mechanics and pose a risk for articular damage. The method proposed in this study, which accounts for both morphological and kinematic characteristics, might help in identifying in a clinical setting patients who, as a consequence of altered femoral torsional alignment, present more severe functional impairments and altered joint mechanics and are therefore at a higher risk for cartilage damage and early onset of hip osteoarthritis.https://www.frontiersin.org/articles/10.3389/fbioe.2021.679360/fullfemoral torsionhip osteoarthritiship contact forcesmuscle lever armsmusculoskeletal modelingEOS imaging |
| spellingShingle | Enrico De Pieri Enrico De Pieri Enrico De Pieri Bernd Friesenbichler Renate List Samara Monn Nicola C. Casartelli Nicola C. Casartelli Michael Leunig Stephen J. Ferguson Subject-Specific Modeling of Femoral Torsion Influences the Prediction of Hip Loading During Gait in Asymptomatic Adults Frontiers in Bioengineering and Biotechnology femoral torsion hip osteoarthritis hip contact forces muscle lever arms musculoskeletal modeling EOS imaging |
| title | Subject-Specific Modeling of Femoral Torsion Influences the Prediction of Hip Loading During Gait in Asymptomatic Adults |
| title_full | Subject-Specific Modeling of Femoral Torsion Influences the Prediction of Hip Loading During Gait in Asymptomatic Adults |
| title_fullStr | Subject-Specific Modeling of Femoral Torsion Influences the Prediction of Hip Loading During Gait in Asymptomatic Adults |
| title_full_unstemmed | Subject-Specific Modeling of Femoral Torsion Influences the Prediction of Hip Loading During Gait in Asymptomatic Adults |
| title_short | Subject-Specific Modeling of Femoral Torsion Influences the Prediction of Hip Loading During Gait in Asymptomatic Adults |
| title_sort | subject specific modeling of femoral torsion influences the prediction of hip loading during gait in asymptomatic adults |
| topic | femoral torsion hip osteoarthritis hip contact forces muscle lever arms musculoskeletal modeling EOS imaging |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.679360/full |
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