Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective
During the past decades, metabolism and redox imbalance have gained considerable attention in the cancer field. In addition to the well-known Warburg effect occurring in tumor cells, numerous other metabolic deregulations have now been reported. Indeed, metabolic reprograming in cancer is much more...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/3/399 |
| _version_ | 1797408556218056704 |
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| author | Géraldine Gentric Fatima Mechta-Grigoriou |
| author_facet | Géraldine Gentric Fatima Mechta-Grigoriou |
| author_sort | Géraldine Gentric |
| collection | DOAJ |
| description | During the past decades, metabolism and redox imbalance have gained considerable attention in the cancer field. In addition to the well-known Warburg effect occurring in tumor cells, numerous other metabolic deregulations have now been reported. Indeed, metabolic reprograming in cancer is much more heterogeneous than initially thought. In particular, a high diversity of carbon sources used by tumor cells has now been shown to contribute to this metabolic heterogeneity in cancer. Moreover, the molecular mechanisms newly highlighted are multiple and shed light on novel actors. Furthermore, the impact of this metabolic heterogeneity on tumor microenvironment has also been an intense subject of research recently. Here, we will describe the new metabolic pathways newly uncovered in tumor cells. We will also have a particular focus on Cancer-Associated Fibroblasts (CAF), whose identity, function and metabolism have been recently under profound investigation. In that sense, we will discuss about the metabolic crosstalk between tumor cells and CAF. |
| first_indexed | 2024-03-09T04:01:14Z |
| format | Article |
| id | doaj.art-3150de13a5d349e383557c91c31acabc |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T04:01:14Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3150de13a5d349e383557c91c31acabc2023-12-03T14:12:58ZengMDPI AGCancers2072-66942021-01-0113339910.3390/cancers13030399Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic PerspectiveGéraldine Gentric0Fatima Mechta-Grigoriou1Institut Curie, Stress and Cancer Laboratory, Equipe Labélisée par la Ligue Nationale Contre le Cancer, PSL Research University, 26, rue d’Ulm, F-75248 Paris, FranceInstitut Curie, Stress and Cancer Laboratory, Equipe Labélisée par la Ligue Nationale Contre le Cancer, PSL Research University, 26, rue d’Ulm, F-75248 Paris, FranceDuring the past decades, metabolism and redox imbalance have gained considerable attention in the cancer field. In addition to the well-known Warburg effect occurring in tumor cells, numerous other metabolic deregulations have now been reported. Indeed, metabolic reprograming in cancer is much more heterogeneous than initially thought. In particular, a high diversity of carbon sources used by tumor cells has now been shown to contribute to this metabolic heterogeneity in cancer. Moreover, the molecular mechanisms newly highlighted are multiple and shed light on novel actors. Furthermore, the impact of this metabolic heterogeneity on tumor microenvironment has also been an intense subject of research recently. Here, we will describe the new metabolic pathways newly uncovered in tumor cells. We will also have a particular focus on Cancer-Associated Fibroblasts (CAF), whose identity, function and metabolism have been recently under profound investigation. In that sense, we will discuss about the metabolic crosstalk between tumor cells and CAF.https://www.mdpi.com/2072-6694/13/3/399metabolismOXPHOScancer cellCAFfibroblasttumor microenvironment |
| spellingShingle | Géraldine Gentric Fatima Mechta-Grigoriou Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective Cancers metabolism OXPHOS cancer cell CAF fibroblast tumor microenvironment |
| title | Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective |
| title_full | Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective |
| title_fullStr | Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective |
| title_full_unstemmed | Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective |
| title_short | Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective |
| title_sort | tumor cells and cancer associated fibroblasts an updated metabolic perspective |
| topic | metabolism OXPHOS cancer cell CAF fibroblast tumor microenvironment |
| url | https://www.mdpi.com/2072-6694/13/3/399 |
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