Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom <i>Ganoderma australe</i>
Two triterpenes, ganoaustralins A (<b>1</b>) and B (<b>2</b>), featuring unprecedented 6/6/6/5/6 scaffolds were isolated from the fruiting bodies of the mushroom <i>Ganoderma australe</i>. The structures were determined by extensive NMR and HRESIMS spectroscopic a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/12/1520 |
| _version_ | 1797455763773325312 |
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| author | Lin Zhou He-Ping Chen Xinyang Li Ji-Kai Liu |
| author_facet | Lin Zhou He-Ping Chen Xinyang Li Ji-Kai Liu |
| author_sort | Lin Zhou |
| collection | DOAJ |
| description | Two triterpenes, ganoaustralins A (<b>1</b>) and B (<b>2</b>), featuring unprecedented 6/6/6/5/6 scaffolds were isolated from the fruiting bodies of the mushroom <i>Ganoderma australe</i>. The structures were determined by extensive NMR and HRESIMS spectroscopic analysis. The absolute configuration of the C-25 in ganoaustralin A was assigned by the phenylglycine methyl ester (PGME) method. The relative and absolute configurations of the polycyclic backbones were determined by NMR and ECD calculations, respectively. The plausible biosynthetic pathways of ganoaustralins A and B were proposed. Ganoaustralin B showed weak inhibition against <i>β</i>-secretase 1. |
| first_indexed | 2024-03-09T15:59:08Z |
| format | Article |
| id | doaj.art-3151ae57ee5f4ad2a1c5978a0a50d371 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T15:59:08Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-3151ae57ee5f4ad2a1c5978a0a50d3712023-11-24T17:16:36ZengMDPI AGPharmaceuticals1424-82472022-12-011512152010.3390/ph15121520Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom <i>Ganoderma australe</i>Lin Zhou0He-Ping Chen1Xinyang Li2Ji-Kai Liu3School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaSchool of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, ChinaTwo triterpenes, ganoaustralins A (<b>1</b>) and B (<b>2</b>), featuring unprecedented 6/6/6/5/6 scaffolds were isolated from the fruiting bodies of the mushroom <i>Ganoderma australe</i>. The structures were determined by extensive NMR and HRESIMS spectroscopic analysis. The absolute configuration of the C-25 in ganoaustralin A was assigned by the phenylglycine methyl ester (PGME) method. The relative and absolute configurations of the polycyclic backbones were determined by NMR and ECD calculations, respectively. The plausible biosynthetic pathways of ganoaustralins A and B were proposed. Ganoaustralin B showed weak inhibition against <i>β</i>-secretase 1.https://www.mdpi.com/1424-8247/15/12/1520<i>Ganoderma australe</i> (Fr.) Pat.Polyporaceaetriterpenesanti-BACE1 activity |
| spellingShingle | Lin Zhou He-Ping Chen Xinyang Li Ji-Kai Liu Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom <i>Ganoderma australe</i> Pharmaceuticals <i>Ganoderma australe</i> (Fr.) Pat. Polyporaceae triterpenes anti-BACE1 activity |
| title | Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom <i>Ganoderma australe</i> |
| title_full | Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom <i>Ganoderma australe</i> |
| title_fullStr | Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom <i>Ganoderma australe</i> |
| title_full_unstemmed | Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom <i>Ganoderma australe</i> |
| title_short | Ganoaustralins A and B, Unusual Aromatic Triterpenes from the Mushroom <i>Ganoderma australe</i> |
| title_sort | ganoaustralins a and b unusual aromatic triterpenes from the mushroom i ganoderma australe i |
| topic | <i>Ganoderma australe</i> (Fr.) Pat. Polyporaceae triterpenes anti-BACE1 activity |
| url | https://www.mdpi.com/1424-8247/15/12/1520 |
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