Mutant p53 as a Regulator and Target of Autophagy
One of the most notoriously altered genes in human cancer is the tumor-suppressor TP53, which is mutated with high frequency in more cancers than any other tumor suppressor gene. Beyond the loss of wild-type p53 functions, mutations in the TP53 gene often lead to the expression of full-length protei...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.607149/full |
| _version_ | 1819055513527123968 |
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| author | Yong Shi Erik Norberg Helin Vakifahmetoglu-Norberg |
| author_facet | Yong Shi Erik Norberg Helin Vakifahmetoglu-Norberg |
| author_sort | Yong Shi |
| collection | DOAJ |
| description | One of the most notoriously altered genes in human cancer is the tumor-suppressor TP53, which is mutated with high frequency in more cancers than any other tumor suppressor gene. Beyond the loss of wild-type p53 functions, mutations in the TP53 gene often lead to the expression of full-length proteins with new malignant properties. Among the defined oncogenic functions of mutant p53 is its effect on cell metabolism and autophagy. Due to the importance of autophagy as a stress adaptive response, it is frequently dysfunctional in human cancers. However, the role of p53 is enigmatic in autophagy regulation. While the complex action of the wild-type p53 on autophagy has extensively been described in literature, in this review, we focus on the conceivable role of distinct mutant p53 proteins in regulating different autophagic pathways and further discuss the available evidence suggesting a possible autophagy stimulatory role of mutant p53. Moreover, we describe the involvement of different autophagic pathways in targeting and degrading mutant p53 proteins, exploring the potential strategies of targeting mutant p53 in cancer by autophagy. |
| first_indexed | 2024-12-21T13:08:43Z |
| format | Article |
| id | doaj.art-31523a751e704fa0a9d93f161d35b182 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T13:08:43Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-31523a751e704fa0a9d93f161d35b1822022-12-21T19:02:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011010.3389/fonc.2020.607149607149Mutant p53 as a Regulator and Target of AutophagyYong ShiErik NorbergHelin Vakifahmetoglu-NorbergOne of the most notoriously altered genes in human cancer is the tumor-suppressor TP53, which is mutated with high frequency in more cancers than any other tumor suppressor gene. Beyond the loss of wild-type p53 functions, mutations in the TP53 gene often lead to the expression of full-length proteins with new malignant properties. Among the defined oncogenic functions of mutant p53 is its effect on cell metabolism and autophagy. Due to the importance of autophagy as a stress adaptive response, it is frequently dysfunctional in human cancers. However, the role of p53 is enigmatic in autophagy regulation. While the complex action of the wild-type p53 on autophagy has extensively been described in literature, in this review, we focus on the conceivable role of distinct mutant p53 proteins in regulating different autophagic pathways and further discuss the available evidence suggesting a possible autophagy stimulatory role of mutant p53. Moreover, we describe the involvement of different autophagic pathways in targeting and degrading mutant p53 proteins, exploring the potential strategies of targeting mutant p53 in cancer by autophagy.https://www.frontiersin.org/articles/10.3389/fonc.2020.607149/fullautophagychaperone-mediated autophagycancermutant p53TP53 |
| spellingShingle | Yong Shi Erik Norberg Helin Vakifahmetoglu-Norberg Mutant p53 as a Regulator and Target of Autophagy Frontiers in Oncology autophagy chaperone-mediated autophagy cancer mutant p53 TP53 |
| title | Mutant p53 as a Regulator and Target of Autophagy |
| title_full | Mutant p53 as a Regulator and Target of Autophagy |
| title_fullStr | Mutant p53 as a Regulator and Target of Autophagy |
| title_full_unstemmed | Mutant p53 as a Regulator and Target of Autophagy |
| title_short | Mutant p53 as a Regulator and Target of Autophagy |
| title_sort | mutant p53 as a regulator and target of autophagy |
| topic | autophagy chaperone-mediated autophagy cancer mutant p53 TP53 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.607149/full |
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