Diagnostic value of blood concentrations of the cytokines of IL-ip, IL-6, and TNF-a and serum amyloid A (SAA) precursor protein in patients with juvenile rheumatoid arthritis
Objective: to reveal the specific features of kidney injury in children with juvenile rheumatoid arthritis (JRA) and to compare findings with the concentrations of serum amyloid A (SAA) precursor protein and the proinflammatory cytokines IL-ip, IL-6, and TNF-a. Results. Twenty (4,5%) of 44 patients...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Ltd. “The National Academy of Pediatric Science and Innovation”
2016-03-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
| Subjects: | |
| Online Access: | https://www.ped-perinatology.ru/jour/article/view/161 |
| Summary: | Objective: to reveal the specific features of kidney injury in children with juvenile rheumatoid arthritis (JRA) and to compare findings with the concentrations of serum amyloid A (SAA) precursor protein and the proinflammatory cytokines IL-ip, IL-6, and TNF-a. Results. Twenty (4,5%) of 44 patients aged 3 to 17 years were found to have systemic-onset JRA; 24 (54,5%) had articular-onset JRA. Twenty-six (59.1%) patients had normal urinalyses; 18 (40,9%) were diagnosed with proteinuria. All the 44 patients were ascertained to have elevated blood SAA protein concentrations. There were no statistically significant differences between the patients with systemic-onset JRA and those with articular-onset JRA in this indicator (333,7+55,2 and 227,3+39,5 mg/1, respectively). The increased blood concentrations of IL-ip and IL-6 were detected in 20 (45,5%) and 17 (38,6%) of the 44 patients. In the patients with systemic-onset JRA, the levels of IL-ip (91,2+18,1 pg/ml) and IL-6 (80,4+18,6 pg/ml) were established to be significantly higher than those (41,4+10,6 and 29,8+5,6 pg/ml, respectively) in the children with articular-onset JRA (/K0,05). Significantly higher serum levels of IL-ip (124,7+23,6 pg/ml) and IL-6 (102,4+27,8 pg/ml) were detected in the systemic-onset JRA patients having proteinuria than those (38,4+16,0 and 43,2+15,2 pg/ml, respectively) in the patients without the latter. The children with JRA showed moderate positive correlations between the elevated blood concentrations of SAA protein and IL-lp and between the blood levels of SAA and IL-6. The findings suggest that the proinflammatory cytokines play a role in maintaining the chronic inflammatory process and stimulating amyloidogenesis in children with JRA. |
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| ISSN: | 1027-4065 2500-2228 |