Two Distinct Interferon-γ in the Orange-Spotted Grouper (Epinephelus coioides): Molecular Cloning, Functional Characterization, and Regulation in Toll-Like Receptor Pathway by Induction of miR-146a

Two Distinct Interferon-γ in the Orange-Spotted Grouper (Epinephelus coioides): Molecular Cloning, Functional Characterization, and Regulation in Toll-Like Receptor Pathway by Induction of miR-146a

Interferon gamma (IFNγ) is a Th1 cytokine that is critical for innate and adaptive immunity. Toll-like receptors (TLRs) signaling pathways are critical in early host defense against invading pathogens. miR-146a has been reported to participate in the regulation of host immunity. The known mechanisms...

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Bibliographic Details
Main Authors: Wan Peng, Yan Sun, Gao-Fei Li, Liang-Ge He, Ruo-Zhu Li, Yao-Si Liang, Xu Ding, Xue Yu, Yong Zhang, Hao-Ran Lin, Dan-Qi Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Endocrinology
Subjects:
Epinephelus coioides
IFNγ1
IFNγ2
miR-146a
TNF receptor-associated factor 6
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2018.00041/full

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