“Let Food Be Thy Medicine”: Gluten and Potential Role in Neurodegeneration
Wheat is a most favored staple food worldwide and its major protein is gluten. It is involved in several gluten dependent diseases and lately was suggested to play a role in non-celiac autoimmune diseases. Its involvement in neurodegenerative conditions was recently suggested but no cause-and-effect...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/4/756 |
| _version_ | 1797539526093045760 |
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| author | Aaron Lerner Carina Benzvi |
| author_facet | Aaron Lerner Carina Benzvi |
| author_sort | Aaron Lerner |
| collection | DOAJ |
| description | Wheat is a most favored staple food worldwide and its major protein is gluten. It is involved in several gluten dependent diseases and lately was suggested to play a role in non-celiac autoimmune diseases. Its involvement in neurodegenerative conditions was recently suggested but no cause-and-effect relationship were established. The present narrative review expands on various aspects of the gluten-gut-brain axes events, mechanisms and pathways that connect wheat and gluten consumption to neurodegenerative disease. Gluten induced dysbiosis, increased intestinal permeabillity, enteric and systemic side effects, cross-reactive antibodies, and the sequence of homologies between brain antigens and gluten are highlighted. This combination may suggest molecular mimicry, alluding to some autoimmune aspects between gluten and neurodegenerative disease. The proverb of Hippocrates coined in 400 BC, “let food be thy medicine,” is critically discussed in the frame of gluten and potential neurodegeneration evolvement. |
| first_indexed | 2024-03-10T12:47:11Z |
| format | Article |
| id | doaj.art-31538af981f54eb49cde82632e167029 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T12:47:11Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-31538af981f54eb49cde82632e1670292023-11-21T13:21:41ZengMDPI AGCells2073-44092021-03-0110475610.3390/cells10040756“Let Food Be Thy Medicine”: Gluten and Potential Role in NeurodegenerationAaron Lerner0Carina Benzvi1Chaim Sheba Medical Center, The Zabludowicz Research Center for Autoimmune Diseases, Tel Hashomer 5262000, IsraelChaim Sheba Medical Center, The Zabludowicz Research Center for Autoimmune Diseases, Tel Hashomer 5262000, IsraelWheat is a most favored staple food worldwide and its major protein is gluten. It is involved in several gluten dependent diseases and lately was suggested to play a role in non-celiac autoimmune diseases. Its involvement in neurodegenerative conditions was recently suggested but no cause-and-effect relationship were established. The present narrative review expands on various aspects of the gluten-gut-brain axes events, mechanisms and pathways that connect wheat and gluten consumption to neurodegenerative disease. Gluten induced dysbiosis, increased intestinal permeabillity, enteric and systemic side effects, cross-reactive antibodies, and the sequence of homologies between brain antigens and gluten are highlighted. This combination may suggest molecular mimicry, alluding to some autoimmune aspects between gluten and neurodegenerative disease. The proverb of Hippocrates coined in 400 BC, “let food be thy medicine,” is critically discussed in the frame of gluten and potential neurodegeneration evolvement.https://www.mdpi.com/2073-4409/10/4/756glutennutrientsintestinebrainneurodegenerationgut-brain axis |
| spellingShingle | Aaron Lerner Carina Benzvi “Let Food Be Thy Medicine”: Gluten and Potential Role in Neurodegeneration Cells gluten nutrients intestine brain neurodegeneration gut-brain axis |
| title | “Let Food Be Thy Medicine”: Gluten and Potential Role in Neurodegeneration |
| title_full | “Let Food Be Thy Medicine”: Gluten and Potential Role in Neurodegeneration |
| title_fullStr | “Let Food Be Thy Medicine”: Gluten and Potential Role in Neurodegeneration |
| title_full_unstemmed | “Let Food Be Thy Medicine”: Gluten and Potential Role in Neurodegeneration |
| title_short | “Let Food Be Thy Medicine”: Gluten and Potential Role in Neurodegeneration |
| title_sort | let food be thy medicine gluten and potential role in neurodegeneration |
| topic | gluten nutrients intestine brain neurodegeneration gut-brain axis |
| url | https://www.mdpi.com/2073-4409/10/4/756 |
| work_keys_str_mv | AT aaronlerner letfoodbethymedicineglutenandpotentialroleinneurodegeneration AT carinabenzvi letfoodbethymedicineglutenandpotentialroleinneurodegeneration |