The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions
Inflammation is increasingly being understood to be a key component to the pathophysiology of cerebrovascular lesions. Ferumoxytol, an iron oxide nanoparticle coated by a carbohydrate shell, has been used in MRI studies as an inflammatory marker because it is cleared by macrophages. Ferumoxytol-enha...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/8/9670 |
| _version_ | 1828821095550025728 |
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| author | David Hasan Nohra Chalouhi Pascal Jabbour Vincent Magnotta |
| author_facet | David Hasan Nohra Chalouhi Pascal Jabbour Vincent Magnotta |
| author_sort | David Hasan |
| collection | DOAJ |
| description | Inflammation is increasingly being understood to be a key component to the pathophysiology of cerebrovascular lesions. Ferumoxytol, an iron oxide nanoparticle coated by a carbohydrate shell, has been used in MRI studies as an inflammatory marker because it is cleared by macrophages. Ferumoxytol-enhanced MRI has emerged as an important tool for noninvasive assessment of the inflammatory status of cerebrovascular lesions, namely aneurysms and arteriovenous malformations. Moreover, preliminary evidence suggests that ferumoxytol-enhanced MRI could be applied as a non-invasive tool to differentiate “unstable” lesions that require early intervention from “stable” lesions in which observation may be safe. Assessment of the effects of anti-inflammatory pharmacological interventions on cerebrovascular lesions is also a potentially crucial application of the technique. Future improvements in technique and MRI signal quantification will certainly pave the way for widespread and efficient use of ferumoxytol-enhanced MRI in clinical practice. In this paper, we review current data regarding ferumoxytol-enhanced MRI and discuss its current/potential applications and future perspectives. |
| first_indexed | 2024-12-12T12:47:53Z |
| format | Article |
| id | doaj.art-3156f4d3ce124609a9cb2436e8a353c3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-12T12:47:53Z |
| publishDate | 2013-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3156f4d3ce124609a9cb2436e8a353c32022-12-22T00:24:04ZengMDPI AGMolecules1420-30492013-08-011889670968310.3390/molecules18089670The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular LesionsDavid HasanNohra ChalouhiPascal JabbourVincent MagnottaInflammation is increasingly being understood to be a key component to the pathophysiology of cerebrovascular lesions. Ferumoxytol, an iron oxide nanoparticle coated by a carbohydrate shell, has been used in MRI studies as an inflammatory marker because it is cleared by macrophages. Ferumoxytol-enhanced MRI has emerged as an important tool for noninvasive assessment of the inflammatory status of cerebrovascular lesions, namely aneurysms and arteriovenous malformations. Moreover, preliminary evidence suggests that ferumoxytol-enhanced MRI could be applied as a non-invasive tool to differentiate “unstable” lesions that require early intervention from “stable” lesions in which observation may be safe. Assessment of the effects of anti-inflammatory pharmacological interventions on cerebrovascular lesions is also a potentially crucial application of the technique. Future improvements in technique and MRI signal quantification will certainly pave the way for widespread and efficient use of ferumoxytol-enhanced MRI in clinical practice. In this paper, we review current data regarding ferumoxytol-enhanced MRI and discuss its current/potential applications and future perspectives.http://www.mdpi.com/1420-3049/18/8/9670aneurysmferumoxytolarteriovenous malformationmagnetic resonance imaginginflammation |
| spellingShingle | David Hasan Nohra Chalouhi Pascal Jabbour Vincent Magnotta The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions Molecules aneurysm ferumoxytol arteriovenous malformation magnetic resonance imaging inflammation |
| title | The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions |
| title_full | The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions |
| title_fullStr | The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions |
| title_full_unstemmed | The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions |
| title_short | The Emerging Role of Ferumoxytol-Enhanced MRI in the Management of Cerebrovascular Lesions |
| title_sort | emerging role of ferumoxytol enhanced mri in the management of cerebrovascular lesions |
| topic | aneurysm ferumoxytol arteriovenous malformation magnetic resonance imaging inflammation |
| url | http://www.mdpi.com/1420-3049/18/8/9670 |
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