Intracellular Trafficking of Size-Tuned Nanoparticles for Drug Delivery

Intracellular Trafficking of Size-Tuned Nanoparticles for Drug Delivery

Polymeric nanoparticles (NPs) are widely used as drug delivery systems in nanomedicine. Despite their widespread application, a comprehensive understanding of their intracellular trafficking remains elusive. In the present study, we focused on exploring the impact of a 20 nm difference in size on NP...

Full description

Bibliographic Details
Main Authors:	Sara Gimondi, Helena Ferreira, Rui L. Reis, Nuno M. Neves
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Series:	International Journal of Molecular Sciences
Subjects:	polymeric nanoparticles size-controlled nanoparticles PEGylation internalization intracellular trafficking
Online Access:	https://www.mdpi.com/1422-0067/25/1/312

Similar Items

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles
by: Parisa Foroozandeh, et al.
Published: (2018-10-01)

Uptake and Intracellular Trafficking Studies of Multiple Dye-Doped Core-Shell Silica Nanoparticles in Lymphoid and Myeloid Cells
by: Sola F, et al.
Published: (2021-03-01)

Polycaprolactone Nanoparticles as Promising Candidates for Nanocarriers in Novel Nanomedicines
by: Sylwia Łukasiewicz, et al.
Published: (2021-02-01)

Optimized Polyethylene Glycolylated Polymer–Lipid Hybrid Nanoparticles as a Potential Breast Cancer Treatment
by: Salam Massadeh, et al.
Published: (2020-07-01)

Surface Exposure of PEG and Amines on Biodegradable Nanoparticles as a Strategy to Tune Their Interaction with Protein-Rich Biological Media
by: Claudia Conte, et al.
Published: (2019-09-01)

Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules
by: María Francisca Matus, et al.
Published: (2018-05-01)

Influence of Folate-Targeted Gold Nanoparticles on Subcellular Localization and Distribution into Lysosomes
by: Raffaella Daniele, et al.
Published: (2023-03-01)

Improved intestinal absorption of paclitaxel by mixed micelles self-assembled from vitamin E succinate-based amphiphilic polymers and their transcellular transport mechanism and intracellular trafficking routes
by: Xiaoyou Qu, et al.
Published: (2018-01-01)

Ultrasonic Transformation of Antibiotic Molecules into a Selective Chemotherapeutic Nanodrug
by: Haiyan Zhu, et al.
Published: (2023-06-01)

Nanotechnological Strategies for Protein Delivery
by: María Rocío Villegas, et al.
Published: (2018-04-01)

Attachment, Entry, and Intracellular Trafficking of Classical Swine Fever Virus
by: Xin Guo, et al.
Published: (2023-09-01)

Intracellular trafficking of new anticancer therapeutics: antibody–drug conjugates
by: Kalim M, et al.
Published: (2017-08-01)

Craniofacial Diseases Caused by Defects in Intracellular Trafficking
by: Chung-Ling Lu, et al.
Published: (2021-05-01)

Fluorescence and electron microscopy to visualize the intracellular fate of nanoparticles for drug delivery
by: M. Costanzo, et al.
Published: (2016-04-01)

Cyclic Peptide-Gadolinium Nanoparticles for Enhanced Intracellular Delivery
by: Amir Nasrolahi Shirazi, et al.
Published: (2020-08-01)

Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA
by: Radu Mihaila, et al.
Published: (2017-06-01)

A novel nanoparticle drug delivery system based on PEGylated hemoglobin for cancer therapy
by: Yongmei Zhao, et al.
Published: (2019-01-01)

Overview of how HCMV manipulation of host cell intracellular trafficking networks can promote productive infection
by: Bailey S. Mosher, et al.
Published: (2022-11-01)

The upregulated intestinal folate transporters direct the uptake of ligand-modified nanoparticles for enhanced oral insulin delivery
by: Jingyi Li, et al.
Published: (2022-03-01)

The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation
by: Judith Hounjet, et al.
Published: (2021-09-01)

Understanding the intracellular trafficking and intercellular transport of potexviruses in their host plant
by: Mi-Ri ePark, et al.
Published: (2014-03-01)

Developed simvastatin chitosan nanoparticles co-crosslinked with tripolyphosphate and chondroitin sulfate for ASGPR-mediated targeted HCC delivery with enhanced oral bioavailability
by: Tarek M. Faris, et al.
Published: (2020-12-01)

Polymeric Nanoparticles for the Treatment of Malignant Gliomas
by: Basant Salah Mahmoud, et al.
Published: (2020-01-01)

COMO ESTUDAR INTERAÇÕES ENTRE NANOPARTÍCULAS E SISTEMAS BIOLÓGICOS
by: Allan Radaic, et al.

Lipid-coated polymeric nanoparticles for cancer drug delivery
by: Krishnamurthy, Sangeetha, et al.
Published: (2015)

Red CdSe/ZnS QDs’ Intracellular Trafficking and Its Impact on Yeast Polarization and Actin Filament
by: Nhi Le, et al.
Published: (2023-02-01)

Mutant Huntingtin affects toll-like receptor 4 intracellular trafficking and cytokine production in mast cells
by: Marian Jesabel Pérez-Rodríguez, et al.
Published: (2020-03-01)

Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases
by: Xingxing Chen, et al.
Published: (2023-02-01)

Acid-labile chemical bonds-based nanoparticles for endosome escape and intracellular delivery
by: Ruoyu Cheng, et al.
Published: (2023-09-01)

Dendronized Silver Nanoparticles as Bacterial Membrane Permeabilizers and Their Interactions With P. aeruginosa Lipopolysaccharides, Lysozymes, and Phage-Derived Endolysins
by: Karol Ciepluch, et al.
Published: (2019-12-01)

Enhance transgene responses through improving cellular uptake and intracellular trafficking by bio-inspired non-viral vectors
by: Xi-Xi Ma, et al.
Published: (2020-01-01)

Mesoporous Organosilica Nanoparticles to Fight Intracellular Staphylococcal Aureus Infections in Macrophages
by: Manasi Jambhrunkar, et al.
Published: (2023-03-01)

Upconverting-photon quenching-mediated perforation influx as an intracellular delivery method using posAuNP@UCNPs nanocomposites for osteoarthritis treatment
by: Hye Jin Kim, et al.
Published: (2024-01-01)

The role of size in PEGylated liposomal doxorubicin biodistribution and anti‐tumour activity
by: Saba Dadpour, et al.
Published: (2022-09-01)

Idiosyncratic Biogenesis of Intracellular Pathogens-Containing Vacuoles
by: Bethany Vaughn, et al.
Published: (2021-11-01)

Intracellular Routing and Recognition of Lipid-Based mRNA Nanoparticles
by: Christophe Delehedde, et al.
Published: (2021-06-01)

Rifampicin-Loaded Mesoporous Silica Nanoparticles for the Treatment of Intracellular Infections
by: Santhni Subramaniam, et al.
Published: (2019-04-01)

Inhalable PEGylated Phospholipid Nanocarriers and PEGylated Therapeutics for Respiratory Delivery as Aerosolized Colloidal Dispersions and Dry Powder Inhalers
by: Priya Muralidharan, et al.
Published: (2014-06-01)

Transient Coexpression of Individual Genes Encoded by the Triple Gene Block of Potato mop-top virus Reveals Requirements for TGBp1 Trafficking
by: Andrey A. Zamyatnin, et al.
Published: (2004-08-01)

Cellular journey of nanomaterials: Theories, trafficking, and kinetics
by: Xiangrui Wang, et al.
Published: (2023-12-01)