Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model

Impaired interactions of ataxin-3 with protein complexes reveals their specific structure and functions in SCA3 Ki150 model

Spinocerebellar ataxia type 3 (SCA3/MJD) is a neurodegenerative disease caused by CAG expansion in mutant ATXN3 gene. The resulting PolyQ tract in mutant ataxin-3 protein is toxic to neurons and currently no effective treatment exists. Function of both normal and mutant ataxin-3 is pleiotropic by th...

Full description

Bibliographic Details
Main Authors: Piotr Piasecki, Kalina Wiatr, Milosz Ruszkowski, Łukasz Marczak, Yvon Trottier, Maciej Figiel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Molecular Neuroscience
Subjects:
SCA3
ataxin-3
CAG
polyQ
neurodegeneration
mouse mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1122308/full

Similar Items

Similar Items