Production of Fumaric Acid by <i>Rhizopus arrhizus</i> NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess
Fumaric acid is a promising monomer to obtain biomass-based polyesters and polyamides, and it is mainly produced by fungi of the <i>Rhizopus</i> genus in medium to high titters. The use of glucose, a main component of starchy and cellulosic food waste, as carbon source, together with a l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Fermentation |
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| Online Access: | https://www.mdpi.com/2311-5637/8/2/64 |
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| author | Victor Martin-Dominguez Paula I. Aleman Cabrera Laslo Eidt Ulf Pruesse Anja Kuenz Miguel Ladero Victoria E. Santos |
| author_facet | Victor Martin-Dominguez Paula I. Aleman Cabrera Laslo Eidt Ulf Pruesse Anja Kuenz Miguel Ladero Victoria E. Santos |
| author_sort | Victor Martin-Dominguez |
| collection | DOAJ |
| description | Fumaric acid is a promising monomer to obtain biomass-based polyesters and polyamides, and it is mainly produced by fungi of the <i>Rhizopus</i> genus in medium to high titters. The use of glucose, a main component of starchy and cellulosic food waste, as carbon source, together with a low-nitrogen source concentration, is a promising route to reduce process costs. In this work, the effects of nitrogen and carbonate sources on <i>Rhizopus arrhizus</i> NRRL 1526 morphology and fumaric acid productivity were analysed, simplifying the traditional production broth composition. Moreover, a non-structured, non-segregated kinetic model was proposed and fitted to concentration data of all relevant components obtained in batches performed in triplicate with the selected production broth at 34 °C and 200 rpm in an orbital shaker. |
| first_indexed | 2024-03-09T22:00:21Z |
| format | Article |
| id | doaj.art-3158b689b1f746b19fe0d560ac67e920 |
| institution | Directory Open Access Journal |
| issn | 2311-5637 |
| language | English |
| last_indexed | 2024-03-09T22:00:21Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Fermentation |
| spelling | doaj.art-3158b689b1f746b19fe0d560ac67e9202023-11-23T19:50:03ZengMDPI AGFermentation2311-56372022-01-01826410.3390/fermentation8020064Production of Fumaric Acid by <i>Rhizopus arrhizus</i> NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the BioprocessVictor Martin-Dominguez0Paula I. Aleman Cabrera1Laslo Eidt2Ulf Pruesse3Anja Kuenz4Miguel Ladero5Victoria E. Santos6FQPIMA Group, Materials and Chemical Engineering Department, Chemical Science School, Complutense University of Madrid, 28040 Madrid, SpainFQPIMA Group, Materials and Chemical Engineering Department, Chemical Science School, Complutense University of Madrid, 28040 Madrid, SpainThünen Institute of Agricultural Technology, 38116 Braunschweig, GermanyThünen Institute of Agricultural Technology, 38116 Braunschweig, GermanyThünen Institute of Agricultural Technology, 38116 Braunschweig, GermanyFQPIMA Group, Materials and Chemical Engineering Department, Chemical Science School, Complutense University of Madrid, 28040 Madrid, SpainFQPIMA Group, Materials and Chemical Engineering Department, Chemical Science School, Complutense University of Madrid, 28040 Madrid, SpainFumaric acid is a promising monomer to obtain biomass-based polyesters and polyamides, and it is mainly produced by fungi of the <i>Rhizopus</i> genus in medium to high titters. The use of glucose, a main component of starchy and cellulosic food waste, as carbon source, together with a low-nitrogen source concentration, is a promising route to reduce process costs. In this work, the effects of nitrogen and carbonate sources on <i>Rhizopus arrhizus</i> NRRL 1526 morphology and fumaric acid productivity were analysed, simplifying the traditional production broth composition. Moreover, a non-structured, non-segregated kinetic model was proposed and fitted to concentration data of all relevant components obtained in batches performed in triplicate with the selected production broth at 34 °C and 200 rpm in an orbital shaker.https://www.mdpi.com/2311-5637/8/2/64fumaric acid<i>Rhizopus arrhizus</i>kinetic modellingfermentation |
| spellingShingle | Victor Martin-Dominguez Paula I. Aleman Cabrera Laslo Eidt Ulf Pruesse Anja Kuenz Miguel Ladero Victoria E. Santos Production of Fumaric Acid by <i>Rhizopus arrhizus</i> NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess Fermentation fumaric acid <i>Rhizopus arrhizus</i> kinetic modelling fermentation |
| title | Production of Fumaric Acid by <i>Rhizopus arrhizus</i> NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess |
| title_full | Production of Fumaric Acid by <i>Rhizopus arrhizus</i> NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess |
| title_fullStr | Production of Fumaric Acid by <i>Rhizopus arrhizus</i> NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess |
| title_full_unstemmed | Production of Fumaric Acid by <i>Rhizopus arrhizus</i> NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess |
| title_short | Production of Fumaric Acid by <i>Rhizopus arrhizus</i> NRRL 1526: A Simple Production Medium and the Kinetic Modelling of the Bioprocess |
| title_sort | production of fumaric acid by i rhizopus arrhizus i nrrl 1526 a simple production medium and the kinetic modelling of the bioprocess |
| topic | fumaric acid <i>Rhizopus arrhizus</i> kinetic modelling fermentation |
| url | https://www.mdpi.com/2311-5637/8/2/64 |
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