Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents
Cancer is one of the most serious human diseases, causing millions of deaths worldwide annually, and, therefore, it is one of the most investigated research disciplines. Developing efficient anticancer tools includes studying the effects of different natural enzymes of plant and microbial origin on...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/12/3836 |
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| author | Akmal M. Asrorov Bahtiyor Muhitdinov Bin Tu Sharafitdin Mirzaakhmedov Huiyuan Wang Yongzhuo Huang |
| author_facet | Akmal M. Asrorov Bahtiyor Muhitdinov Bin Tu Sharafitdin Mirzaakhmedov Huiyuan Wang Yongzhuo Huang |
| author_sort | Akmal M. Asrorov |
| collection | DOAJ |
| description | Cancer is one of the most serious human diseases, causing millions of deaths worldwide annually, and, therefore, it is one of the most investigated research disciplines. Developing efficient anticancer tools includes studying the effects of different natural enzymes of plant and microbial origin on tumor cells. The development of various smart delivery systems based on enzyme drugs has been conducted for more than two decades. Some of these delivery systems have been developed to the point that they have reached clinical stages, and a few have even found application in selected cancer treatments. Various biological, chemical, and physical approaches have been utilized to enhance their efficiencies by improving their delivery and targeting. In this paper, we review advanced delivery systems for enzyme drugs for use in cancer therapy. Their structure-based functions, mechanisms of action, fused forms with other peptides in terms of targeting and penetration, and other main results from in vivo and clinical studies of these advanced delivery systems are highlighted. |
| first_indexed | 2024-03-09T22:54:56Z |
| format | Article |
| id | doaj.art-315a83372d564d2fa211503990c5f6f8 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T22:54:56Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-315a83372d564d2fa211503990c5f6f82023-11-23T18:12:08ZengMDPI AGMolecules1420-30492022-06-012712383610.3390/molecules27123836Advances on Delivery of Cytotoxic Enzymes as Anticancer AgentsAkmal M. Asrorov0Bahtiyor Muhitdinov1Bin Tu2Sharafitdin Mirzaakhmedov3Huiyuan Wang4Yongzhuo Huang5Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaInstitute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent 100125, UzbekistanShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaCancer is one of the most serious human diseases, causing millions of deaths worldwide annually, and, therefore, it is one of the most investigated research disciplines. Developing efficient anticancer tools includes studying the effects of different natural enzymes of plant and microbial origin on tumor cells. The development of various smart delivery systems based on enzyme drugs has been conducted for more than two decades. Some of these delivery systems have been developed to the point that they have reached clinical stages, and a few have even found application in selected cancer treatments. Various biological, chemical, and physical approaches have been utilized to enhance their efficiencies by improving their delivery and targeting. In this paper, we review advanced delivery systems for enzyme drugs for use in cancer therapy. Their structure-based functions, mechanisms of action, fused forms with other peptides in terms of targeting and penetration, and other main results from in vivo and clinical studies of these advanced delivery systems are highlighted.https://www.mdpi.com/1420-3049/27/12/3836enzyme drugscancer therapytrichosanthingeloninperoxidaseglucose oxidase |
| spellingShingle | Akmal M. Asrorov Bahtiyor Muhitdinov Bin Tu Sharafitdin Mirzaakhmedov Huiyuan Wang Yongzhuo Huang Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents Molecules enzyme drugs cancer therapy trichosanthin gelonin peroxidase glucose oxidase |
| title | Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents |
| title_full | Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents |
| title_fullStr | Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents |
| title_full_unstemmed | Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents |
| title_short | Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents |
| title_sort | advances on delivery of cytotoxic enzymes as anticancer agents |
| topic | enzyme drugs cancer therapy trichosanthin gelonin peroxidase glucose oxidase |
| url | https://www.mdpi.com/1420-3049/27/12/3836 |
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