Harnessing supramolecular peptide nanotechnology in biomedical applications
Kiat Hwa Chan,1 Wei Hao Lee,2 Shuangmu Zhuo,3 Ming Ni3 1Division of Science, Yale-NUS College, Singapore; 2Department of Chemistry, Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, MD, USA; 3Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-02-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/harnessing-supramolecular-peptide-nanotechnology-in-biomedical-applica-peer-reviewed-article-IJN |
| _version_ | 1819021703869628416 |
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| author | Chan KH Lee WH Zhuo S Ni M |
| author_facet | Chan KH Lee WH Zhuo S Ni M |
| author_sort | Chan KH |
| collection | DOAJ |
| description | Kiat Hwa Chan,1 Wei Hao Lee,2 Shuangmu Zhuo,3 Ming Ni3 1Division of Science, Yale-NUS College, Singapore; 2Department of Chemistry, Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, MD, USA; 3Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, People’s Republic of China Abstract: The harnessing of peptides in biomedical applications is a recent hot topic. This arises mainly from the general biocompatibility of peptides, as well as from the ease of tunability of peptide structure to engineer desired properties. The ease of progression from laboratory testing to clinical trials is evident from the plethora of examples available. In this review, we compare and contrast how three distinct self-assembled peptide nanostructures possess different functions. We have 1) nanofibrils in biomaterials that can interact with cells, 2) nanoparticles that can traverse the bloodstream to deliver its payload and also be bioimaged, and 3) nanotubes that can serve as cross-membrane conduits and as a template for nanowire formation. Through this review, we aim to illustrate how various peptides, in their various self-assembled nanostructures, possess great promise in a wide range of biomedical applications and what more can be expected. Keywords: peptides, self-assembly, nanotechnology |
| first_indexed | 2024-12-21T04:11:19Z |
| format | Article |
| id | doaj.art-315ac2fec7dd41ebb9f1287a5c4212b8 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-21T04:11:19Z |
| publishDate | 2017-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-315ac2fec7dd41ebb9f1287a5c4212b82022-12-21T19:16:27ZengDove Medical PressInternational Journal of Nanomedicine1178-20132017-02-01Volume 121171118231230Harnessing supramolecular peptide nanotechnology in biomedical applicationsChan KHLee WHZhuo SNi MKiat Hwa Chan,1 Wei Hao Lee,2 Shuangmu Zhuo,3 Ming Ni3 1Division of Science, Yale-NUS College, Singapore; 2Department of Chemistry, Krieger School of Arts & Sciences, Johns Hopkins University, Baltimore, MD, USA; 3Fujian Provincial Key Laboratory for Photonics Technology, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fuzhou, People’s Republic of China Abstract: The harnessing of peptides in biomedical applications is a recent hot topic. This arises mainly from the general biocompatibility of peptides, as well as from the ease of tunability of peptide structure to engineer desired properties. The ease of progression from laboratory testing to clinical trials is evident from the plethora of examples available. In this review, we compare and contrast how three distinct self-assembled peptide nanostructures possess different functions. We have 1) nanofibrils in biomaterials that can interact with cells, 2) nanoparticles that can traverse the bloodstream to deliver its payload and also be bioimaged, and 3) nanotubes that can serve as cross-membrane conduits and as a template for nanowire formation. Through this review, we aim to illustrate how various peptides, in their various self-assembled nanostructures, possess great promise in a wide range of biomedical applications and what more can be expected. Keywords: peptides, self-assembly, nanotechnologyhttps://www.dovepress.com/harnessing-supramolecular-peptide-nanotechnology-in-biomedical-applica-peer-reviewed-article-IJNpeptidesself-assemblynanotechnology |
| spellingShingle | Chan KH Lee WH Zhuo S Ni M Harnessing supramolecular peptide nanotechnology in biomedical applications International Journal of Nanomedicine peptides self-assembly nanotechnology |
| title | Harnessing supramolecular peptide nanotechnology in biomedical applications |
| title_full | Harnessing supramolecular peptide nanotechnology in biomedical applications |
| title_fullStr | Harnessing supramolecular peptide nanotechnology in biomedical applications |
| title_full_unstemmed | Harnessing supramolecular peptide nanotechnology in biomedical applications |
| title_short | Harnessing supramolecular peptide nanotechnology in biomedical applications |
| title_sort | harnessing supramolecular peptide nanotechnology in biomedical applications |
| topic | peptides self-assembly nanotechnology |
| url | https://www.dovepress.com/harnessing-supramolecular-peptide-nanotechnology-in-biomedical-applica-peer-reviewed-article-IJN |
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