Role of Spectrin in Endocytosis
Cytoskeletal spectrin is found in (non)erythroid cells. Eukaryotic endocytosis takes place for internalizing cargos from extracellular milieu. The role of spectrin in endocytosis still remains poorly understood. Here, I summarize current knowledge of spectrin function, spectrin-based cytoskeleton an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/15/2459 |
| _version_ | 1797442424713248768 |
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| author | Donghai Li |
| author_facet | Donghai Li |
| author_sort | Donghai Li |
| collection | DOAJ |
| description | Cytoskeletal spectrin is found in (non)erythroid cells. Eukaryotic endocytosis takes place for internalizing cargos from extracellular milieu. The role of spectrin in endocytosis still remains poorly understood. Here, I summarize current knowledge of spectrin function, spectrin-based cytoskeleton and endocytosis of erythrocytes, and highlight how spectrin contributes to endocytosis and working models in different types of cells. From an evolutionary viewpoint, I discuss spectrin and endocytosis in a range of organisms, particularly in plants and yeast where spectrin is absent. Together, the role of spectrin in endocytosis is related to its post-translational modification, movement/rearrangement, elimination (by proteases) and meshwork fencing. |
| first_indexed | 2024-03-09T12:41:39Z |
| format | Article |
| id | doaj.art-315ae988e0b84130bf95b079484de6a3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T12:41:39Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-315ae988e0b84130bf95b079484de6a32023-11-30T22:16:42ZengMDPI AGCells2073-44092022-08-011115245910.3390/cells11152459Role of Spectrin in EndocytosisDonghai Li0State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, ChinaCytoskeletal spectrin is found in (non)erythroid cells. Eukaryotic endocytosis takes place for internalizing cargos from extracellular milieu. The role of spectrin in endocytosis still remains poorly understood. Here, I summarize current knowledge of spectrin function, spectrin-based cytoskeleton and endocytosis of erythrocytes, and highlight how spectrin contributes to endocytosis and working models in different types of cells. From an evolutionary viewpoint, I discuss spectrin and endocytosis in a range of organisms, particularly in plants and yeast where spectrin is absent. Together, the role of spectrin in endocytosis is related to its post-translational modification, movement/rearrangement, elimination (by proteases) and meshwork fencing.https://www.mdpi.com/2073-4409/11/15/2459cytoskeletonendocytosisevolutionspectrin |
| spellingShingle | Donghai Li Role of Spectrin in Endocytosis Cells cytoskeleton endocytosis evolution spectrin |
| title | Role of Spectrin in Endocytosis |
| title_full | Role of Spectrin in Endocytosis |
| title_fullStr | Role of Spectrin in Endocytosis |
| title_full_unstemmed | Role of Spectrin in Endocytosis |
| title_short | Role of Spectrin in Endocytosis |
| title_sort | role of spectrin in endocytosis |
| topic | cytoskeleton endocytosis evolution spectrin |
| url | https://www.mdpi.com/2073-4409/11/15/2459 |
| work_keys_str_mv | AT donghaili roleofspectrininendocytosis |