Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles
The global pandemic of COVID-19 had a consequential impact on our lives. (Hydroxy)chloroquine, a well-known drug for treatment or prevention against malaria and chronic inflammatory conditions, was also used for COVID patients with reported potential efficacy. Although it was well tolerated, however...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-02-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535222007845 |
| _version_ | 1797952757740601344 |
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| author | Anju Manuja Dharvi Chhabra Balvinder Kumar |
| author_facet | Anju Manuja Dharvi Chhabra Balvinder Kumar |
| author_sort | Anju Manuja |
| collection | DOAJ |
| description | The global pandemic of COVID-19 had a consequential impact on our lives. (Hydroxy)chloroquine, a well-known drug for treatment or prevention against malaria and chronic inflammatory conditions, was also used for COVID patients with reported potential efficacy. Although it was well tolerated, however in some cases, it produced severe side effects, including grave cardiac issues. The variable reports on the administration of (hydroxy)chloroquine in COVID19 patients led to chaos. This drug is a well-known zinc ionophore, besides possessing antiviral effects. Zinc ionophores augment the intracellular Zn2+ concentration by facilitating the zinc ions into the cells and subsequently impair virus replication. Zinc oxide nanoparticles (ZnO NPs) have been reported to possess antiviral activity. However, the adverse effects of both components are also reported. We discussed in depth their possible mechanism as antiviral and smart delivery perspectives through pH-sensitive polymers/ micelles and ZnO NPs. |
| first_indexed | 2024-04-10T22:52:18Z |
| format | Article |
| id | doaj.art-315db80b2ff34a93bd5abe2bc1275b05 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-04-10T22:52:18Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-315db80b2ff34a93bd5abe2bc1275b052023-01-15T04:21:37ZengElsevierArabian Journal of Chemistry1878-53522023-02-01162104468Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticlesAnju Manuja0Dharvi Chhabra1Balvinder Kumar2Corresponding authors at: ICAR-National Research Centre on Equines, Hisar-125001, Haryana, India.; ICAR-National Research Centre on Equines, Hisar, Haryana 125001, IndiaICAR-National Research Centre on Equines, Hisar, Haryana 125001, IndiaCorresponding authors at: ICAR-National Research Centre on Equines, Hisar-125001, Haryana, India.; ICAR-National Research Centre on Equines, Hisar, Haryana 125001, IndiaThe global pandemic of COVID-19 had a consequential impact on our lives. (Hydroxy)chloroquine, a well-known drug for treatment or prevention against malaria and chronic inflammatory conditions, was also used for COVID patients with reported potential efficacy. Although it was well tolerated, however in some cases, it produced severe side effects, including grave cardiac issues. The variable reports on the administration of (hydroxy)chloroquine in COVID19 patients led to chaos. This drug is a well-known zinc ionophore, besides possessing antiviral effects. Zinc ionophores augment the intracellular Zn2+ concentration by facilitating the zinc ions into the cells and subsequently impair virus replication. Zinc oxide nanoparticles (ZnO NPs) have been reported to possess antiviral activity. However, the adverse effects of both components are also reported. We discussed in depth their possible mechanism as antiviral and smart delivery perspectives through pH-sensitive polymers/ micelles and ZnO NPs.http://www.sciencedirect.com/science/article/pii/S1878535222007845ZnO nanoparticlesCOVID 19ChloroquinepH responsiveMicellesPolymers |
| spellingShingle | Anju Manuja Dharvi Chhabra Balvinder Kumar Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles Arabian Journal of Chemistry ZnO nanoparticles COVID 19 Chloroquine pH responsive Micelles Polymers |
| title | Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles |
| title_full | Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles |
| title_fullStr | Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles |
| title_full_unstemmed | Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles |
| title_short | Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles |
| title_sort | chloroquine chaos and covid 19 smart delivery perspectives through ph sensitive polymers micelles and zno nanoparticles |
| topic | ZnO nanoparticles COVID 19 Chloroquine pH responsive Micelles Polymers |
| url | http://www.sciencedirect.com/science/article/pii/S1878535222007845 |
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