Histone variant macroH2A1 rewires carbohydrate and lipid metabolism of hepatocellular carcinoma cells towards cancer stem cells

Histone variant macroH2A1 rewires carbohydrate and lipid metabolism of hepatocellular carcinoma cells towards cancer stem cells

Hepatocellular carcinomas (HCCs) contain a sub-population of cancer stem cells (CSCs) that are responsible for tumor relapse, metastasis, and chemoresistance. We recently showed that loss of macroH2A1, a variant of the histone H2A and an epigenetic regulator of stem-cell function, in HCC leads to CS...

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Bibliographic Details
Main Authors: Oriana Lo Re, Julien Douet, Marcus Buschbeck, Caterina Fusilli, Valerio Pazienza, Concetta Panebianco, Carlo Castruccio Castracani, Tommaso Mazza, Giovanni Li Volti, Manlio Vinciguerra
Format: Article
Language:English
Published: Taylor & Francis Group 2018-08-01
Series:Epigenetics
Subjects:
histone variants
cancer stem cells
hepatocellular carcinoma
Online Access:http://dx.doi.org/10.1080/15592294.2018.1514239

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