Postinjection delirium/sedation syndrome with olanzapine depot injection

After 1 year of introduction of olanzapine long-acting injectable (LAI) in India, many psychiatrists believe that it is a very affordable, well-tolerated, and effective second generation long-acting antipsychotic depot compared to not well tolerated but cheap first generation antipsychotic depots an...

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Main Authors: Sadhvi Mythili Sarangula, Starlin Vijay Mythri, Y Sanjay, M S Reddy
Format: Article
Language:English
Published: SAGE Publishing 2016-01-01
Series:Indian Journal of Psychological Medicine
Subjects:
Online Access:http://www.ijpm.info/article.asp?issn=0253-7176;year=2016;volume=38;issue=4;spage=366;epage=369;aulast=Sarangula
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author Sadhvi Mythili Sarangula
Starlin Vijay Mythri
Y Sanjay
M S Reddy
author_facet Sadhvi Mythili Sarangula
Starlin Vijay Mythri
Y Sanjay
M S Reddy
author_sort Sadhvi Mythili Sarangula
collection DOAJ
description After 1 year of introduction of olanzapine long-acting injectable (LAI) in India, many psychiatrists believe that it is a very affordable, well-tolerated, and effective second generation long-acting antipsychotic depot compared to not well tolerated but cheap first generation antipsychotic depots and to other second generation depots which are costly. However, reports of its possible adverse events in clinical settings are not yet published. We report what probably might be the first case of postinjection delirium/sedation syndrome (PDSS) in India. Although the occurrence is uncommon, incorrect understanding of this event may hinder the future use of the potentially useful olanzapine LAI. We review the available literature on the proposed diagnostic guidelines, mechanism of this event, precautions, and management of PDSS.
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spelling doaj.art-316165dafadb44e5aabfc967b0dba0022022-12-21T18:33:58ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71762016-01-0138436636910.4103/0253-7176.185946Postinjection delirium/sedation syndrome with olanzapine depot injectionSadhvi Mythili SarangulaStarlin Vijay MythriY SanjayM S ReddyAfter 1 year of introduction of olanzapine long-acting injectable (LAI) in India, many psychiatrists believe that it is a very affordable, well-tolerated, and effective second generation long-acting antipsychotic depot compared to not well tolerated but cheap first generation antipsychotic depots and to other second generation depots which are costly. However, reports of its possible adverse events in clinical settings are not yet published. We report what probably might be the first case of postinjection delirium/sedation syndrome (PDSS) in India. Although the occurrence is uncommon, incorrect understanding of this event may hinder the future use of the potentially useful olanzapine LAI. We review the available literature on the proposed diagnostic guidelines, mechanism of this event, precautions, and management of PDSS.http://www.ijpm.info/article.asp?issn=0253-7176;year=2016;volume=38;issue=4;spage=366;epage=369;aulast=SarangulaAdverse eventslong-acting injectionolanzapine pamoatepostinjection delirium/sedation syndromeschizophrenia
spellingShingle Sadhvi Mythili Sarangula
Starlin Vijay Mythri
Y Sanjay
M S Reddy
Postinjection delirium/sedation syndrome with olanzapine depot injection
Indian Journal of Psychological Medicine
Adverse events
long-acting injection
olanzapine pamoate
postinjection delirium/sedation syndrome
schizophrenia
title Postinjection delirium/sedation syndrome with olanzapine depot injection
title_full Postinjection delirium/sedation syndrome with olanzapine depot injection
title_fullStr Postinjection delirium/sedation syndrome with olanzapine depot injection
title_full_unstemmed Postinjection delirium/sedation syndrome with olanzapine depot injection
title_short Postinjection delirium/sedation syndrome with olanzapine depot injection
title_sort postinjection delirium sedation syndrome with olanzapine depot injection
topic Adverse events
long-acting injection
olanzapine pamoate
postinjection delirium/sedation syndrome
schizophrenia
url http://www.ijpm.info/article.asp?issn=0253-7176;year=2016;volume=38;issue=4;spage=366;epage=369;aulast=Sarangula
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AT starlinvijaymythri postinjectiondeliriumsedationsyndromewitholanzapinedepotinjection
AT ysanjay postinjectiondeliriumsedationsyndromewitholanzapinedepotinjection
AT msreddy postinjectiondeliriumsedationsyndromewitholanzapinedepotinjection