Cateslytin, a chromogranin A derived peptide is active against Staphylococcus aureus and resistant to degradation by its proteases.
Innate immunity involving antimicrobial peptides represents an integrated and highly effective system of molecular and cellular mechanisms that protects host against infections. One of the most frequent hospital-acquired pathogens, Staphylococcus aureus, capable of producing proteolytic enzymes, whi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3722296?pdf=render |
| _version_ | 1811292465012932608 |
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| author | Rizwan Aslam Céline Marban Christian Corazzol François Jehl François Delalande Alain Van Dorsselaer Gilles Prévost Youssef Haïkel Corinne Taddei Francis Schneider Marie-Hélène Metz-Boutigue |
| author_facet | Rizwan Aslam Céline Marban Christian Corazzol François Jehl François Delalande Alain Van Dorsselaer Gilles Prévost Youssef Haïkel Corinne Taddei Francis Schneider Marie-Hélène Metz-Boutigue |
| author_sort | Rizwan Aslam |
| collection | DOAJ |
| description | Innate immunity involving antimicrobial peptides represents an integrated and highly effective system of molecular and cellular mechanisms that protects host against infections. One of the most frequent hospital-acquired pathogens, Staphylococcus aureus, capable of producing proteolytic enzymes, which can degrade the host defence agents and tissue components. Numerous antimicrobial peptides derived from chromogranins, are secreted by nervous, endocrine and immune cells during stress conditions. These kill microorganisms by their lytic effect at micromolar range, using a pore-forming mechanism against Gram-positive bacteria, filamentous fungi and yeasts. In this study, we tested antimicrobial activity of chromogranin A-derived peptides (catestatin and cateslytin) against S. aureus and analysed S. aureus-mediated proteolysis of these peptides using HPLC, sequencing and MALDI-TOF mass spectrometry. Interestingly, this study is the first to demonstrate that cateslytin, the active domain of catestatin, is active against S. aureus and is interestingly resistant to degradation by S. aureus proteases. |
| first_indexed | 2024-04-13T04:45:45Z |
| format | Article |
| id | doaj.art-3161b11be70544edba4ed664c0060106 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T04:45:45Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3161b11be70544edba4ed664c00601062022-12-22T03:01:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6899310.1371/journal.pone.0068993Cateslytin, a chromogranin A derived peptide is active against Staphylococcus aureus and resistant to degradation by its proteases.Rizwan AslamCéline MarbanChristian CorazzolFrançois JehlFrançois DelalandeAlain Van DorsselaerGilles PrévostYoussef HaïkelCorinne TaddeiFrancis SchneiderMarie-Hélène Metz-BoutigueInnate immunity involving antimicrobial peptides represents an integrated and highly effective system of molecular and cellular mechanisms that protects host against infections. One of the most frequent hospital-acquired pathogens, Staphylococcus aureus, capable of producing proteolytic enzymes, which can degrade the host defence agents and tissue components. Numerous antimicrobial peptides derived from chromogranins, are secreted by nervous, endocrine and immune cells during stress conditions. These kill microorganisms by their lytic effect at micromolar range, using a pore-forming mechanism against Gram-positive bacteria, filamentous fungi and yeasts. In this study, we tested antimicrobial activity of chromogranin A-derived peptides (catestatin and cateslytin) against S. aureus and analysed S. aureus-mediated proteolysis of these peptides using HPLC, sequencing and MALDI-TOF mass spectrometry. Interestingly, this study is the first to demonstrate that cateslytin, the active domain of catestatin, is active against S. aureus and is interestingly resistant to degradation by S. aureus proteases.http://europepmc.org/articles/PMC3722296?pdf=render |
| spellingShingle | Rizwan Aslam Céline Marban Christian Corazzol François Jehl François Delalande Alain Van Dorsselaer Gilles Prévost Youssef Haïkel Corinne Taddei Francis Schneider Marie-Hélène Metz-Boutigue Cateslytin, a chromogranin A derived peptide is active against Staphylococcus aureus and resistant to degradation by its proteases. PLoS ONE |
| title | Cateslytin, a chromogranin A derived peptide is active against Staphylococcus aureus and resistant to degradation by its proteases. |
| title_full | Cateslytin, a chromogranin A derived peptide is active against Staphylococcus aureus and resistant to degradation by its proteases. |
| title_fullStr | Cateslytin, a chromogranin A derived peptide is active against Staphylococcus aureus and resistant to degradation by its proteases. |
| title_full_unstemmed | Cateslytin, a chromogranin A derived peptide is active against Staphylococcus aureus and resistant to degradation by its proteases. |
| title_short | Cateslytin, a chromogranin A derived peptide is active against Staphylococcus aureus and resistant to degradation by its proteases. |
| title_sort | cateslytin a chromogranin a derived peptide is active against staphylococcus aureus and resistant to degradation by its proteases |
| url | http://europepmc.org/articles/PMC3722296?pdf=render |
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