Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults
BACKGROUND High-sensitivity C-reactive protein (hsCRP) has been widely accepted as a predictor of future cardiovascular risk that reflects a microinflammatory state. Obesity linked to microinflammation increases the prevalence of metabolic disorders and cardiovascular diseases. This study aimed to d...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine Trisakti University
2021-01-01
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| Series: | Universa Medicina |
| Subjects: | |
| Online Access: | https://univmed.org/ejurnal/index.php/medicina/article/view/1045 |
| _version_ | 1818646711725195264 |
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| author | Winda Mulyamin Liong Boy Kurniawan Endy Adnan Yuyun Widaningsih Irfan Idris Arif Santoso Ika Yustisia |
| author_facet | Winda Mulyamin Liong Boy Kurniawan Endy Adnan Yuyun Widaningsih Irfan Idris Arif Santoso Ika Yustisia |
| author_sort | Winda Mulyamin |
| collection | DOAJ |
| description | BACKGROUND
High-sensitivity C-reactive protein (hsCRP) has been widely accepted as a predictor of future cardiovascular risk that reflects a microinflammatory state. Obesity linked to microinflammation increases the prevalence of metabolic disorders and cardiovascular diseases. This study aimed to determine the association between several obesity indices namely body mass index (BMI), waist circumference (WC), body fat percentage (fat), and visceral fat (VF) with hsCRP in non-diabetic adults.
METHODS
This was a cross-sectional study performed on 80 non-diabetic adults with ages ranging from 20-40 years. The obesity indices BMI, WC, body fat percentage, and VF were measured. We then measured the hsCRP levels using an immunoturbidimetric method. Simple and multiple linear regression tests were used to analyze the association between obesity indices and hsCRP levels.
RESULTS
Mean of log BMI, log WC, and log VF was 1.41 ± 0.08 kg/m2, 1.93 ± 0.06 cm, and 0.95 ± 0.27 units, respectively. Simple linear regression tests showed that log BMI (â=3.506; p<0.001), log WC (â=3.672; p<0.001), log VF (â=0.833; p<0.001), and log systolic blood pressure (â=3.739; p=0.024) had a significant positive correlation with log hsCRP levels. Further multiple linear regression test showed that log BMI (â=3.772; Beta=0.674; p<0.001) had the greater effect on log hsCRP levels compared to other indices.
CONCLUSIONS
BMI had a greater influence on hsCRP levels compared to other obesity indices in non-diabetic adults. Body mass index can be used as a better index in predicting hsCRP levels compared to other indices. |
| first_indexed | 2024-12-17T00:50:59Z |
| format | Article |
| id | doaj.art-3162c7a3ea114a39bff5f52c007c3226 |
| institution | Directory Open Access Journal |
| issn | 1907-3062 2407-2230 |
| language | English |
| last_indexed | 2024-12-17T00:50:59Z |
| publishDate | 2021-01-01 |
| publisher | Faculty of Medicine Trisakti University |
| record_format | Article |
| series | Universa Medicina |
| spelling | doaj.art-3162c7a3ea114a39bff5f52c007c32262022-12-21T22:09:46ZengFaculty of Medicine Trisakti UniversityUniversa Medicina1907-30622407-22302021-01-0140110.18051/UnivMed.2021.v40.22-28426Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adultsWinda Mulyamin0Liong Boy Kurniawan1Endy Adnan2Yuyun Widaningsih3Irfan Idris4Arif Santoso5Ika Yustisia6Aging and Regenerative Medicine Concentration, Biomedical Magister Programme, Hasanuddin University, MakassarDepartment of Clinical Pathology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Clinical Pathology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Physiology, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University, MakassarDepartment of Biochemistry, Faculty of Medicine, Hasanuddin University, MakassarBACKGROUND High-sensitivity C-reactive protein (hsCRP) has been widely accepted as a predictor of future cardiovascular risk that reflects a microinflammatory state. Obesity linked to microinflammation increases the prevalence of metabolic disorders and cardiovascular diseases. This study aimed to determine the association between several obesity indices namely body mass index (BMI), waist circumference (WC), body fat percentage (fat), and visceral fat (VF) with hsCRP in non-diabetic adults. METHODS This was a cross-sectional study performed on 80 non-diabetic adults with ages ranging from 20-40 years. The obesity indices BMI, WC, body fat percentage, and VF were measured. We then measured the hsCRP levels using an immunoturbidimetric method. Simple and multiple linear regression tests were used to analyze the association between obesity indices and hsCRP levels. RESULTS Mean of log BMI, log WC, and log VF was 1.41 ± 0.08 kg/m2, 1.93 ± 0.06 cm, and 0.95 ± 0.27 units, respectively. Simple linear regression tests showed that log BMI (â=3.506; p<0.001), log WC (â=3.672; p<0.001), log VF (â=0.833; p<0.001), and log systolic blood pressure (â=3.739; p=0.024) had a significant positive correlation with log hsCRP levels. Further multiple linear regression test showed that log BMI (â=3.772; Beta=0.674; p<0.001) had the greater effect on log hsCRP levels compared to other indices. CONCLUSIONS BMI had a greater influence on hsCRP levels compared to other obesity indices in non-diabetic adults. Body mass index can be used as a better index in predicting hsCRP levels compared to other indices.https://univmed.org/ejurnal/index.php/medicina/article/view/1045Body mass indexwaist circumferencevisceral fatbody fathsCRP |
| spellingShingle | Winda Mulyamin Liong Boy Kurniawan Endy Adnan Yuyun Widaningsih Irfan Idris Arif Santoso Ika Yustisia Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults Universa Medicina Body mass index waist circumference visceral fat body fat hsCRP |
| title | Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults |
| title_full | Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults |
| title_fullStr | Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults |
| title_full_unstemmed | Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults |
| title_short | Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults |
| title_sort | body mass index as the most influential factor of high sensitivity c reactive protein in non diabetic adults |
| topic | Body mass index waist circumference visceral fat body fat hsCRP |
| url | https://univmed.org/ejurnal/index.php/medicina/article/view/1045 |
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