Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities
Withania somnifera (WS) (Dunal) or Ashwagandha is a well-known hypolipidemic herb and antioxidant. In this study, 75% ethanolic extract of WS is attempted to evaluate the cardioprotective activity of isoproterenol-induced cardiotoxicity and hypolipidemic activity in Triton WR 1339-induced hyperlipid...
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| Format: | Article |
| Language: | English |
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Koya University
2021-10-01
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| Series: | ARO-The Scientific Journal of Koya University |
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| Online Access: | http://aro.koyauniversity.org/index.php/aro/article/view/844 |
| _version_ | 1827853549013303296 |
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| author | Subasini Uthirapathy Tara F. Tahir |
| author_facet | Subasini Uthirapathy Tara F. Tahir |
| author_sort | Subasini Uthirapathy |
| collection | DOAJ |
| description | Withania somnifera (WS) (Dunal) or Ashwagandha is a well-known hypolipidemic herb and antioxidant. In this study, 75% ethanolic extract of WS is attempted to evaluate the cardioprotective activity of isoproterenol-induced cardiotoxicity and hypolipidemic activity in Triton WR 1339-induced hyperlipidemia. In addition,
phytochemical evaluation of the same extracts analyzed by gas chromatography–mass spectrometer (GC–MS). This study found that 7 days of therapy with WS extracts at 1000 mg/kg b.wt. reduced cholesterol by 76%, low-density lipoprotein (LDL) by 71%, and TAG by 12% (P < 0.05). Furthermore, it can significantly reduce cholesterol and LDL levels (P < 0.05). Similarly, the use of 50 mg/kg b.wt. of WS extract showed a cardioprotective effect against isoproterenol-induced cardiac toxic rats. The antioxidants glutathione, glutathione peroxidase, and catalase are increased in WS extract (P < 0.05), whereas the release of cardiac indicators in heart tissue is reduced (P < 0.05). Furthermore, a 30-day treatment with WS also reduced triacylglycerol in isoprenaline-induced cardiotoxic rats. GC–MS analysis of the methanol fraction of the Ashwagandha 70% ethanolic extract showed the presence of higher concentrations of fatty acids. In conclusion, WS showed hypolipidemic and cardioprotective activities in diseased animals induced by isoproterenol and Triton WR 1339. |
| first_indexed | 2024-03-12T11:08:22Z |
| format | Article |
| id | doaj.art-3163f618da104a569f6e2a312457ce30 |
| institution | Directory Open Access Journal |
| issn | 2410-9355 2307-549X |
| language | English |
| last_indexed | 2024-03-12T11:08:22Z |
| publishDate | 2021-10-01 |
| publisher | Koya University |
| record_format | Article |
| series | ARO-The Scientific Journal of Koya University |
| spelling | doaj.art-3163f618da104a569f6e2a312457ce302023-09-02T03:22:33ZengKoya UniversityARO-The Scientific Journal of Koya University2410-93552307-549X2021-10-019210.14500/aro.10844Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective ActivitiesSubasini Uthirapathy0Tara F. Tahir1Department of Pharmacology, Faculty of Pharmacy, Tishk International University, Kurdistan Region - F.R. IraqDepartment of Chemistry, Faculty of Science and Health, Koya University, Kurdistan Region - F.R. IraqWithania somnifera (WS) (Dunal) or Ashwagandha is a well-known hypolipidemic herb and antioxidant. In this study, 75% ethanolic extract of WS is attempted to evaluate the cardioprotective activity of isoproterenol-induced cardiotoxicity and hypolipidemic activity in Triton WR 1339-induced hyperlipidemia. In addition, phytochemical evaluation of the same extracts analyzed by gas chromatography–mass spectrometer (GC–MS). This study found that 7 days of therapy with WS extracts at 1000 mg/kg b.wt. reduced cholesterol by 76%, low-density lipoprotein (LDL) by 71%, and TAG by 12% (P < 0.05). Furthermore, it can significantly reduce cholesterol and LDL levels (P < 0.05). Similarly, the use of 50 mg/kg b.wt. of WS extract showed a cardioprotective effect against isoproterenol-induced cardiac toxic rats. The antioxidants glutathione, glutathione peroxidase, and catalase are increased in WS extract (P < 0.05), whereas the release of cardiac indicators in heart tissue is reduced (P < 0.05). Furthermore, a 30-day treatment with WS also reduced triacylglycerol in isoprenaline-induced cardiotoxic rats. GC–MS analysis of the methanol fraction of the Ashwagandha 70% ethanolic extract showed the presence of higher concentrations of fatty acids. In conclusion, WS showed hypolipidemic and cardioprotective activities in diseased animals induced by isoproterenol and Triton WR 1339.http://aro.koyauniversity.org/index.php/aro/article/view/844AntioxidantsCardiac markersGas chromatography–mass spectrometerIsoproterenolLipidTriton WR 1339 |
| spellingShingle | Subasini Uthirapathy Tara F. Tahir Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities ARO-The Scientific Journal of Koya University Antioxidants Cardiac markers Gas chromatography–mass spectrometer Isoproterenol Lipid Triton WR 1339 |
| title | Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities |
| title_full | Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities |
| title_fullStr | Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities |
| title_full_unstemmed | Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities |
| title_short | Withania Somnifera: Correlation of Phytoconstituents with Hypolipidemic and Cardioprotective Activities |
| title_sort | withania somnifera correlation of phytoconstituents with hypolipidemic and cardioprotective activities |
| topic | Antioxidants Cardiac markers Gas chromatography–mass spectrometer Isoproterenol Lipid Triton WR 1339 |
| url | http://aro.koyauniversity.org/index.php/aro/article/view/844 |
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