POSSIBILITIES OF ANXIETY-DEPRESSIVE DISORDERS TREATMENT IN PATIENTS WITH CHRONIC HEART FAILURE
Aim. To study the efficacy and safety of D-, L-gopantenic acid/Pantogam active in the complex treatment of congestive heart failure and coronary heart disease in patients with symptoms of anxiety-depressive disorder. Patients and methods. 82 patients with NYHA II-III heart failure, anxiety and depre...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2017-02-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1050 |
| _version_ | 1797856933959434240 |
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| author | A. P. Baranov A. V. Strutynskiy O. Sh. Oynotkinova A. A. Baranova V. V. Trishina Yu. Yu. Golubev A. N. Kruzhalov |
| author_facet | A. P. Baranov A. V. Strutynskiy O. Sh. Oynotkinova A. A. Baranova V. V. Trishina Yu. Yu. Golubev A. N. Kruzhalov |
| author_sort | A. P. Baranov |
| collection | DOAJ |
| description | Aim. To study the efficacy and safety of D-, L-gopantenic acid/Pantogam active in the complex treatment of congestive heart failure and coronary heart disease in patients with symptoms of anxiety-depressive disorder. Patients and methods. 82 patients with NYHA II-III heart failure, anxiety and depression were enrolled in the study.Material and methods. The severity of psychological disorders and the efficacy of 8-week therapy with Pantogam active were assessed using Hamilton Depression Rating Scale (HDRS), Hospital Anxiety and Depression Scale (HADS), State Trait Anxiety Index (STAI), and Clinical Global Impression (CGI) Scale. The quality of life was evaluated using the Short Form 36 (SF-36) Health Survey. Global improvement or change of psychological symptoms by CGI Scale were considered as efficacy criteria. Standard diagnostic tools, i.e., echocardiography and 24-hour Holter monitoring, were applied as well.Results. 8-week treatment with Pantogam active of patients with heart failure and depression greatly reduces the severity of anxiety-depressive disorders, improves physical activity tolerance and vegetative regulation of heart rhythm, and decreases heart rate in supraventricular and ventricular arrhythmias.Conclusions. In heart failure patients, anxiety-depressive disorders are accompanied by significant disturbances of heart rhythm vegetative regulation, development of supraventricular and ventricular arrhythmias, physical activity intolerance, increased hospital admission rate, and decreased quality of life. 8-week treatment with Pantogam active due to its bimodal action significantly improves these symptoms and the quality of life. |
| first_indexed | 2024-04-09T20:48:35Z |
| format | Article |
| id | doaj.art-31652ef6c6b74863afa68e9abfb35c94 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:48:35Z |
| publishDate | 2017-02-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-31652ef6c6b74863afa68e9abfb35c942023-03-29T21:23:27Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202017-02-010112813510.15829/1560-4071-2017-1-128-135869POSSIBILITIES OF ANXIETY-DEPRESSIVE DISORDERS TREATMENT IN PATIENTS WITH CHRONIC HEART FAILUREA. P. Baranov0A. V. Strutynskiy1O. Sh. Oynotkinova2A. A. Baranova3V. V. Trishina4Yu. Yu. Golubev5A. N. Kruzhalov6N. I. Pirogov Russian National Research Medical UniversityN. I. Pirogov Russian National Research Medical UniversityN. I. Pirogov Russian National Research Medical UniversityN. I. Pirogov Russian National Research Medical UniversityN. I. Pirogov Russian National Research Medical UniversityN. I. Pirogov Russian National Research Medical UniversityCity Clinical Hospital No. 68Aim. To study the efficacy and safety of D-, L-gopantenic acid/Pantogam active in the complex treatment of congestive heart failure and coronary heart disease in patients with symptoms of anxiety-depressive disorder. Patients and methods. 82 patients with NYHA II-III heart failure, anxiety and depression were enrolled in the study.Material and methods. The severity of psychological disorders and the efficacy of 8-week therapy with Pantogam active were assessed using Hamilton Depression Rating Scale (HDRS), Hospital Anxiety and Depression Scale (HADS), State Trait Anxiety Index (STAI), and Clinical Global Impression (CGI) Scale. The quality of life was evaluated using the Short Form 36 (SF-36) Health Survey. Global improvement or change of psychological symptoms by CGI Scale were considered as efficacy criteria. Standard diagnostic tools, i.e., echocardiography and 24-hour Holter monitoring, were applied as well.Results. 8-week treatment with Pantogam active of patients with heart failure and depression greatly reduces the severity of anxiety-depressive disorders, improves physical activity tolerance and vegetative regulation of heart rhythm, and decreases heart rate in supraventricular and ventricular arrhythmias.Conclusions. In heart failure patients, anxiety-depressive disorders are accompanied by significant disturbances of heart rhythm vegetative regulation, development of supraventricular and ventricular arrhythmias, physical activity intolerance, increased hospital admission rate, and decreased quality of life. 8-week treatment with Pantogam active due to its bimodal action significantly improves these symptoms and the quality of life.https://russjcardiol.elpub.ru/jour/article/view/1050anxietydepressionheart failurepantogam activeheart rate variability |
| spellingShingle | A. P. Baranov A. V. Strutynskiy O. Sh. Oynotkinova A. A. Baranova V. V. Trishina Yu. Yu. Golubev A. N. Kruzhalov POSSIBILITIES OF ANXIETY-DEPRESSIVE DISORDERS TREATMENT IN PATIENTS WITH CHRONIC HEART FAILURE Российский кардиологический журнал anxiety depression heart failure pantogam active heart rate variability |
| title | POSSIBILITIES OF ANXIETY-DEPRESSIVE DISORDERS TREATMENT IN PATIENTS WITH CHRONIC HEART FAILURE |
| title_full | POSSIBILITIES OF ANXIETY-DEPRESSIVE DISORDERS TREATMENT IN PATIENTS WITH CHRONIC HEART FAILURE |
| title_fullStr | POSSIBILITIES OF ANXIETY-DEPRESSIVE DISORDERS TREATMENT IN PATIENTS WITH CHRONIC HEART FAILURE |
| title_full_unstemmed | POSSIBILITIES OF ANXIETY-DEPRESSIVE DISORDERS TREATMENT IN PATIENTS WITH CHRONIC HEART FAILURE |
| title_short | POSSIBILITIES OF ANXIETY-DEPRESSIVE DISORDERS TREATMENT IN PATIENTS WITH CHRONIC HEART FAILURE |
| title_sort | possibilities of anxiety depressive disorders treatment in patients with chronic heart failure |
| topic | anxiety depression heart failure pantogam active heart rate variability |
| url | https://russjcardiol.elpub.ru/jour/article/view/1050 |
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