Human eosinophil-lymphocyte interactions
While the eosinophil's effector functions clearly can contribute to the pathogenesis of allergic diseases, the evolutionary benefit to having eosinophils as a distinct class of leukocytes is not clear, especially if one must reconsider the nominally beneficial role of eosinophils in parasite ho...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
1997-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800023 |
| _version_ | 1797721262607302656 |
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| author | Weller Peter F Lim Kaiser |
| author_facet | Weller Peter F Lim Kaiser |
| author_sort | Weller Peter F |
| collection | DOAJ |
| description | While the eosinophil's effector functions clearly can contribute to the pathogenesis of allergic diseases, the evolutionary benefit to having eosinophils as a distinct class of leukocytes is not clear, especially if one must reconsider the nominally beneficial role of eosinophils in parasite host defense. Eosinophils are equipped to respond to lymphocytes and their cytokines (and not solely the eosinophil growth factor cytokines), but the functional consequences of such eosinophil responses need to be defined. Conversely, eosinophils, as antigen-presenting cells (APCs) or sources of lymphocyte-active cytokines, may stimulate and effect lymphocyte functioning. Eosinophils share with CD4+ lymphocytes expression of a number of receptors, including CD4 and IL-2R, and specific alpha4 integrins that may help in their common recruitment and activation. Further, elucidation of the interactions between lymphocytes and eosinophils will contribute to a broader understanding of the functioning of eosinophils in "normal" ongoing immune responses and in allergic disorders. |
| first_indexed | 2024-03-12T09:30:59Z |
| format | Article |
| id | doaj.art-3165abf9e78a40fb91fec96f0378e51e |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T09:30:59Z |
| publishDate | 1997-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-3165abf9e78a40fb91fec96f0378e51e2023-09-02T13:54:09ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601997-01-0192suppl.2173182Human eosinophil-lymphocyte interactionsWeller Peter FLim KaiserWhile the eosinophil's effector functions clearly can contribute to the pathogenesis of allergic diseases, the evolutionary benefit to having eosinophils as a distinct class of leukocytes is not clear, especially if one must reconsider the nominally beneficial role of eosinophils in parasite host defense. Eosinophils are equipped to respond to lymphocytes and their cytokines (and not solely the eosinophil growth factor cytokines), but the functional consequences of such eosinophil responses need to be defined. Conversely, eosinophils, as antigen-presenting cells (APCs) or sources of lymphocyte-active cytokines, may stimulate and effect lymphocyte functioning. Eosinophils share with CD4+ lymphocytes expression of a number of receptors, including CD4 and IL-2R, and specific alpha4 integrins that may help in their common recruitment and activation. Further, elucidation of the interactions between lymphocytes and eosinophils will contribute to a broader understanding of the functioning of eosinophils in "normal" ongoing immune responses and in allergic disorders.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800023human eosinophillymphocite interactionsallergic disorders |
| spellingShingle | Weller Peter F Lim Kaiser Human eosinophil-lymphocyte interactions Memorias do Instituto Oswaldo Cruz human eosinophil lymphocite interactions allergic disorders |
| title | Human eosinophil-lymphocyte interactions |
| title_full | Human eosinophil-lymphocyte interactions |
| title_fullStr | Human eosinophil-lymphocyte interactions |
| title_full_unstemmed | Human eosinophil-lymphocyte interactions |
| title_short | Human eosinophil-lymphocyte interactions |
| title_sort | human eosinophil lymphocyte interactions |
| topic | human eosinophil lymphocite interactions allergic disorders |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800023 |
| work_keys_str_mv | AT wellerpeterf humaneosinophillymphocyteinteractions AT limkaiser humaneosinophillymphocyteinteractions |