Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models

Up-and-coming anti-epileptic effect of aloesone in Aloe vera: Evidenced by integrating network pharmacological analysis, in vitro, and in vivo models

Background:Aloe vera is a medically valuable plant with anti-epileptic activity; however, its mechanism of action remains unknown. In this study, network pharmacological, in vitro, and in vivo experiments were carried out to explore the potential anti-epileptic components and targets of Aloe vera.Me...

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Bibliographic Details
Main Authors: Yan Wang, Chang Li, Zhongyv Xiong, Niangen Chen, Xuesong Wang, Junyv Xu, Yuemei Wang, Longfeng Liu, Hang Wu, Caihui Huang, Aiqin Huang, Jiajia Tan, Youbin Li, Qifu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
Aloe vera
aloesone
network pharmacology
glutamate-induced HT22
PTZ-induced seizure
c-SRC
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.962223/full

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