Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice

Preliminary Evidence of the Potent and Selective Adenosine A2B Receptor Antagonist PSB-603 in Reducing Obesity and Some of Its Associated Metabolic Disorders in Mice

The adenosine A<sub>2A</sub> and A<sub>2B</sub> receptors are promising therapeutic targets in the treatment of obesity and diabetes since the agonists and antagonists of these receptors have the potential to positively affect metabolic disorders. The present study investigat...

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Bibliographic Details
Main Authors: Magdalena Kotańska, Anna Dziubina, Małgorzata Szafarz, Kamil Mika, Marek Bednarski, Noemi Nicosia, Ahmed Temirak, Christa E. Müller, Katarzyna Kieć-Kononowicz
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
adenosine A<sub>2B</sub> receptor antagonist
glucose tolerance
metabolic disorder
obesity
PSB-603
Theophylline
Online Access:https://www.mdpi.com/1422-0067/23/21/13439

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