The Impact of Adipose Tissue–Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer
Obesity is a multifactorial and complex condition that is characterized by abnormal and excessive white adipose tissue accumulation, which can lead to the development of metabolic diseases, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, cardiovascular diseases, and several types...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.563816/full |
| _version_ | 1818260213409513472 |
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| author | Gabriella Simões Heyn Luís Henrique Corrêa Kelly Grace Magalhães |
| author_facet | Gabriella Simões Heyn Luís Henrique Corrêa Kelly Grace Magalhães |
| author_sort | Gabriella Simões Heyn |
| collection | DOAJ |
| description | Obesity is a multifactorial and complex condition that is characterized by abnormal and excessive white adipose tissue accumulation, which can lead to the development of metabolic diseases, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, cardiovascular diseases, and several types of cancer. Obesity is characterized by excessive adipose tissue accumulation and associated with alterations in immunity, displaying a chronic low-grade inflammation profile. Adipose tissue is a dynamic and complex endocrine organ composed not only by adipocytes, but several immunological cells, which can secrete hormones, cytokines and many other factors capable of regulating metabolic homeostasis and several critical biological pathways. Remarkably, adipose tissue is a major source of circulating microRNAs (miRNAs), recently described as a novel form of adipokines. Several adipose tissue–derived miRNAs are deeply associated with adipocytes differentiation and have been identified with an essential role in obesity-associated inflammation, insulin resistance, and tumor microenvironment. During obesity, adipose tissue can completely change the profile of the secreted miRNAs, influencing circulating miRNAs and impacting the development of different pathological conditions, such as obesity, metabolic syndrome, and cancer. In this review, we discuss how miRNAs can act as epigenetic regulators affecting adipogenesis, adipocyte differentiation, lipid metabolism, browning of the white adipose tissue, glucose homeostasis, and insulin resistance, impacting deeply obesity and metabolic diseases. Moreover, we characterize how miRNAs can often act as oncogenic and tumor suppressor molecules, significantly modulating cancer establishment and progression. Furthermore, we highlight in this manuscript how adipose tissue–derived miRNAs can function as important new therapeutic targets. |
| first_indexed | 2024-12-12T18:27:46Z |
| format | Article |
| id | doaj.art-316c1fcad25a4970b4e189e6b1a87844 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T18:27:46Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-316c1fcad25a4970b4e189e6b1a878442022-12-22T00:15:59ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-10-011110.3389/fendo.2020.563816563816The Impact of Adipose Tissue–Derived miRNAs in Metabolic Syndrome, Obesity, and CancerGabriella Simões HeynLuís Henrique CorrêaKelly Grace MagalhãesObesity is a multifactorial and complex condition that is characterized by abnormal and excessive white adipose tissue accumulation, which can lead to the development of metabolic diseases, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, cardiovascular diseases, and several types of cancer. Obesity is characterized by excessive adipose tissue accumulation and associated with alterations in immunity, displaying a chronic low-grade inflammation profile. Adipose tissue is a dynamic and complex endocrine organ composed not only by adipocytes, but several immunological cells, which can secrete hormones, cytokines and many other factors capable of regulating metabolic homeostasis and several critical biological pathways. Remarkably, adipose tissue is a major source of circulating microRNAs (miRNAs), recently described as a novel form of adipokines. Several adipose tissue–derived miRNAs are deeply associated with adipocytes differentiation and have been identified with an essential role in obesity-associated inflammation, insulin resistance, and tumor microenvironment. During obesity, adipose tissue can completely change the profile of the secreted miRNAs, influencing circulating miRNAs and impacting the development of different pathological conditions, such as obesity, metabolic syndrome, and cancer. In this review, we discuss how miRNAs can act as epigenetic regulators affecting adipogenesis, adipocyte differentiation, lipid metabolism, browning of the white adipose tissue, glucose homeostasis, and insulin resistance, impacting deeply obesity and metabolic diseases. Moreover, we characterize how miRNAs can often act as oncogenic and tumor suppressor molecules, significantly modulating cancer establishment and progression. Furthermore, we highlight in this manuscript how adipose tissue–derived miRNAs can function as important new therapeutic targets.https://www.frontiersin.org/article/10.3389/fendo.2020.563816/fullmiRNAadipose tissueobesitycancermetabolic syndrome |
| spellingShingle | Gabriella Simões Heyn Luís Henrique Corrêa Kelly Grace Magalhães The Impact of Adipose Tissue–Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer Frontiers in Endocrinology miRNA adipose tissue obesity cancer metabolic syndrome |
| title | The Impact of Adipose Tissue–Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer |
| title_full | The Impact of Adipose Tissue–Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer |
| title_fullStr | The Impact of Adipose Tissue–Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer |
| title_full_unstemmed | The Impact of Adipose Tissue–Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer |
| title_short | The Impact of Adipose Tissue–Derived miRNAs in Metabolic Syndrome, Obesity, and Cancer |
| title_sort | impact of adipose tissue derived mirnas in metabolic syndrome obesity and cancer |
| topic | miRNA adipose tissue obesity cancer metabolic syndrome |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.563816/full |
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