Thymus involution in alloxan diabetes: analysis of mast cells
We previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thy...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
2005-03-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900022 |
| _version_ | 1797756622196441088 |
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| author | EO Barreto I Riederer ACS Arantes VF Carvalho FA Farias-Filho RSB Cordeiro MA Martins W Savino PMR e Silva |
| author_facet | EO Barreto I Riederer ACS Arantes VF Carvalho FA Farias-Filho RSB Cordeiro MA Martins W Savino PMR e Silva |
| author_sort | EO Barreto |
| collection | DOAJ |
| description | We previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues. |
| first_indexed | 2024-03-12T18:03:17Z |
| format | Article |
| id | doaj.art-316c84cca38842e6aab0df248742ec97 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:03:17Z |
| publishDate | 2005-03-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-316c84cca38842e6aab0df248742ec972023-08-02T09:32:21ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602005-03-0110012713010.1590/S0074-02762005000900022Thymus involution in alloxan diabetes: analysis of mast cellsEO BarretoI RiedererACS ArantesVF CarvalhoFA Farias-FilhoRSB CordeiroMA MartinsW SavinoPMR e SilvaWe previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900022diabetesmast cellsthymusextracellular matrix |
| spellingShingle | EO Barreto I Riederer ACS Arantes VF Carvalho FA Farias-Filho RSB Cordeiro MA Martins W Savino PMR e Silva Thymus involution in alloxan diabetes: analysis of mast cells Memorias do Instituto Oswaldo Cruz diabetes mast cells thymus extracellular matrix |
| title | Thymus involution in alloxan diabetes: analysis of mast cells |
| title_full | Thymus involution in alloxan diabetes: analysis of mast cells |
| title_fullStr | Thymus involution in alloxan diabetes: analysis of mast cells |
| title_full_unstemmed | Thymus involution in alloxan diabetes: analysis of mast cells |
| title_short | Thymus involution in alloxan diabetes: analysis of mast cells |
| title_sort | thymus involution in alloxan diabetes analysis of mast cells |
| topic | diabetes mast cells thymus extracellular matrix |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900022 |
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