Synthesis of various fused pyrimidine rings with their pharmacological and antimicrobial evaluation
Various fused pyrimidine such as furo[2,3-d]pyrimidine, triazolo[1,5-a]pyrimidine, tetrazolo[1,5-a]pyrimidine were synthesized from the reactions of thioxopyrimidine-6(1H)-ones with ethyl chloroacetate (under different reaction conditions), thiourea, and sodium nitrite. Pyrimidine thione...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2014-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2014/0352-51391400016M.pdf |
| Summary: | Various fused pyrimidine such as furo[2,3-d]pyrimidine,
triazolo[1,5-a]pyrimidine, tetrazolo[1,5-a]pyrimidine were synthesized from
the reactions of thioxopyrimidine-6(1H)-ones with ethyl chloroacetate (under
different reaction conditions), thiourea, and sodium nitrite. Pyrimidine
thiones reacted with POCl3/PCl5 to give the chloro derivatives which reacted
with sodium azide, and thiourea to give the tetrazolo[1,5-c]pyrimidine,
pyrimido pyrimidine. Thioxopyrimidine-6(1H)-ones reacted with benzyl amine to
give pyrrolo[2,3-d]pyrimidinethione. Theoretical calculation using MIDO/3,
Fukui indices and the heat of formation of some compounds were carried out.
The pharmacological and antimicrobial activities of some of the synthesized
products were also evaluated. |
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| ISSN: | 0352-5139 1820-7421 |