Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging
A considerable amount of early breast tumors grown at a depth over 2 cm in breast tissues. With high near-infrared absorption of iron-platinum (FePt) nanoparticles, we achieved few centimeters deep photoacoustic (PA) imaging for the diagnosis of breast tumors. The imaging depth can extend over 5 cm...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Photoacoustics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597920300197 |
| _version_ | 1818518175952666624 |
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| author | Yubin Liu Pei-Chun Wu Sen Guo Pi-Tai Chou Chuxia Deng Shang-Wei Chou Zhen Yuan Tzu-Ming Liu |
| author_facet | Yubin Liu Pei-Chun Wu Sen Guo Pi-Tai Chou Chuxia Deng Shang-Wei Chou Zhen Yuan Tzu-Ming Liu |
| author_sort | Yubin Liu |
| collection | DOAJ |
| description | A considerable amount of early breast tumors grown at a depth over 2 cm in breast tissues. With high near-infrared absorption of iron-platinum (FePt) nanoparticles, we achieved few centimeters deep photoacoustic (PA) imaging for the diagnosis of breast tumors. The imaging depth can extend over 5 cm in chicken breast tissues at the low laser energy density of 20 mJ/cm2 (≤ ANSI safety limit). After anti-VEGFR conjugation and the tail-vein injection, we validated their targeting on tumor sites by the confocal microscopy and PA imaging. Using a home-made whole-body in vivo PA imaging, we found that the nanoparticles were rapidly cleared away from the site of the tumor and majorly metabolized through the liver. These results validated the clinical potential of the FePt nanoparticles in the low-toxicity PA theragnosis of early breast cancer and showed the capacity of our whole-body PA imaging technique on monitoring the dynamic biodistribution of nanoparticles in the living body. |
| first_indexed | 2024-12-11T01:06:27Z |
| format | Article |
| id | doaj.art-316d81b4a6554dadaf225bc748d46d66 |
| institution | Directory Open Access Journal |
| issn | 2213-5979 |
| language | English |
| last_indexed | 2024-12-11T01:06:27Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj.art-316d81b4a6554dadaf225bc748d46d662022-12-22T01:26:10ZengElsevierPhotoacoustics2213-59792020-09-0119100179Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imagingYubin Liu0Pei-Chun Wu1Sen Guo2Pi-Tai Chou3Chuxia Deng4Shang-Wei Chou5Zhen Yuan6Tzu-Ming Liu7Cancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, ChinaCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, ChinaCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, ChinaDepartment of Chemistry, National Taiwan University, Taipei, 10617, TaiwanCancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, ChinaDepartment of Chemistry, National Taiwan University, Taipei, 10617, Taiwan; Corresponding author at: Department of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.Cancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China; Corresponding authors.Cancer Center, Faculty of Health Sciences, University of Macau, Macau SAR, China; Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China; Corresponding authors.A considerable amount of early breast tumors grown at a depth over 2 cm in breast tissues. With high near-infrared absorption of iron-platinum (FePt) nanoparticles, we achieved few centimeters deep photoacoustic (PA) imaging for the diagnosis of breast tumors. The imaging depth can extend over 5 cm in chicken breast tissues at the low laser energy density of 20 mJ/cm2 (≤ ANSI safety limit). After anti-VEGFR conjugation and the tail-vein injection, we validated their targeting on tumor sites by the confocal microscopy and PA imaging. Using a home-made whole-body in vivo PA imaging, we found that the nanoparticles were rapidly cleared away from the site of the tumor and majorly metabolized through the liver. These results validated the clinical potential of the FePt nanoparticles in the low-toxicity PA theragnosis of early breast cancer and showed the capacity of our whole-body PA imaging technique on monitoring the dynamic biodistribution of nanoparticles in the living body.http://www.sciencedirect.com/science/article/pii/S2213597920300197Whole-body photoacoustic imagingBreast cancerImaging depthFePt nanoparticles |
| spellingShingle | Yubin Liu Pei-Chun Wu Sen Guo Pi-Tai Chou Chuxia Deng Shang-Wei Chou Zhen Yuan Tzu-Ming Liu Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging Photoacoustics Whole-body photoacoustic imaging Breast cancer Imaging depth FePt nanoparticles |
| title | Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging |
| title_full | Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging |
| title_fullStr | Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging |
| title_full_unstemmed | Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging |
| title_short | Low-toxicity FePt nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole-body photoacoustic imaging |
| title_sort | low toxicity fept nanoparticles for the targeted and enhanced diagnosis of breast tumors using few centimeters deep whole body photoacoustic imaging |
| topic | Whole-body photoacoustic imaging Breast cancer Imaging depth FePt nanoparticles |
| url | http://www.sciencedirect.com/science/article/pii/S2213597920300197 |
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