Efficacy of botulinum toxin in healing of posttraumatic facial lacerations: A prospective, randomized, comparative study

Background: Posttraumatic facial scars are not only unaesthetic but also have a negative sociopsychological impact. Surgeons constantly try to achieve the most aesthetic scar by various suturing methods. The tensile forces acting on the edges of the wound during healing are a major factor in determi...

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Bibliographic Details
Main Authors: Monica S Patil, Kumar Nilesh, Payal P Mate
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Journal of Cutaneous and Aesthetic Surgery
Subjects:
Online Access:http://www.jcasonline.com/article.asp?issn=0974-2077;year=2022;volume=15;issue=3;spage=295;epage=302;aulast=Patil
Description
Summary:Background: Posttraumatic facial scars are not only unaesthetic but also have a negative sociopsychological impact. Surgeons constantly try to achieve the most aesthetic scar by various suturing methods. The tensile forces acting on the edges of the wound during healing are a major factor in determining the final appearance of a scar. Aim: Injecting botulinum toxin type A (BTX-A) locally to produce temporary muscular paralysis to relieve the tensile forces acting on suture line, thus improving the appearance of the scar. Materials and Methods: In this study, patients with posttraumatic facial lacerations were locally injected with BTX-A before suturing (with vicryl 4-0 and ethilon 5-0 in layers). BTX-A reformulated with local anesthetic with vasoconstrictive was used in this study for immediate action. Patients were followed for a duration of 6 months with standardized photographs of the scar for evaluation. Result: A total of 50 patients with traumatic facial lacerations were included in the study. This study demonstrated significantly less increase in scar width (P = 0.000) and irregularities (P = 0.017), and improved discoloration of the scar (P = 0.000) in patients who received BTX-A injection. The overall results showed significant (P < 0.05) improvement over the period of 6 months. Both visual analog scale scoring and patient self-assessment scale were favorable in the BTX-A group, showing statistically significant improvement (P < 0.05). Conclusion: Botulinum toxin-induced immobilization of the wound enhances healing and improves the eventual appearance of the scar.
ISSN:0974-2077