LPS Primes Brain Responsiveness to High Mobility Group Box-1 Protein

LPS Primes Brain Responsiveness to High Mobility Group Box-1 Protein

High mobility group box (HMGB)1 action contributes to late phases of sepsis, but the effects of increased endogenous plasma HMGB1 levels on brain cells during inflammation are unclear. Here, we aimed to further investigate the role of HMGB1 in the brain during septic-like lipopolysaccharide-induced...

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Bibliographic Details
Main Authors: Verena Peek, Lois M. Harden, Jelena Damm, Ferial Aslani, Stephan Leisengang, Joachim Roth, Rüdiger Gerstberger, Marita Meurer, Maren von Köckritz-Blickwede, Sabine Schulz, Bernhard Spengler, Christoph Rummel
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
cytokines
lipopolysaccharide
high mobility group box-1 protein
circumventricular organs
septic-like inflammation
Online Access:https://www.mdpi.com/1424-8247/14/6/558

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