Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract
Elaeis guineensis (Arecaceae) is widely used in West African traditional medicine for treating various ailments. An evaluation on the toxicity of extracts of this plant is crucial to support the therapeutic claims. The acute oral toxicity and brine shrimp lethality of a methanolic extract of this pl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-11-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/11/8111/ |
| _version_ | 1811260282025017344 |
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| author | Yeng Chen Lai Ngit Shin Yee Ling Lau Sreenivasan Sasidharan Yuet Ping Kwan Lachimanan Yoga Latha Soundararajan Vijayarathna Abdul Rani Muhamad Syahmi |
| author_facet | Yeng Chen Lai Ngit Shin Yee Ling Lau Sreenivasan Sasidharan Yuet Ping Kwan Lachimanan Yoga Latha Soundararajan Vijayarathna Abdul Rani Muhamad Syahmi |
| author_sort | Yeng Chen |
| collection | DOAJ |
| description | Elaeis guineensis (Arecaceae) is widely used in West African traditional medicine for treating various ailments. An evaluation on the toxicity of extracts of this plant is crucial to support the therapeutic claims. The acute oral toxicity and brine shrimp lethality of a methanolic extract of this plant was tested. Oral administration of crude extract at the highest dose of 5,000 mg/kg resulted in no mortalities or evidence of adverse effects, implying that E. guineensis is nontoxic. Normal behavioral pattern, clinical signs and histology of vital organs confirm this evidence. The E. guineensis extracts screened for toxicity against brine shrimp had 50% lethal concentration (LC50) values of more than 1.0 mg/mL (9.00 and 3.87 mg/mL, at 6 and 24 h, respectively), confirming that the extract was not toxic. Maximum mortalities occurred at 100 mg/mL concentration while the least mortalities happened to be at 0.195 mg/mL concentration. The results of both tests confirm that E. guineensis is nontoxic and hence safe for commercial utilization. |
| first_indexed | 2024-04-12T18:45:05Z |
| format | Article |
| id | doaj.art-31716cd24e8e4e1395a5b79461008751 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T18:45:05Z |
| publishDate | 2010-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-31716cd24e8e4e1395a5b794610087512022-12-22T03:20:38ZengMDPI AGMolecules1420-30492010-11-0115118111812110.3390/molecules15118111Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol ExtractYeng ChenLai Ngit ShinYee Ling LauSreenivasan SasidharanYuet Ping KwanLachimanan Yoga LathaSoundararajan VijayarathnaAbdul Rani Muhamad SyahmiElaeis guineensis (Arecaceae) is widely used in West African traditional medicine for treating various ailments. An evaluation on the toxicity of extracts of this plant is crucial to support the therapeutic claims. The acute oral toxicity and brine shrimp lethality of a methanolic extract of this plant was tested. Oral administration of crude extract at the highest dose of 5,000 mg/kg resulted in no mortalities or evidence of adverse effects, implying that E. guineensis is nontoxic. Normal behavioral pattern, clinical signs and histology of vital organs confirm this evidence. The E. guineensis extracts screened for toxicity against brine shrimp had 50% lethal concentration (LC50) values of more than 1.0 mg/mL (9.00 and 3.87 mg/mL, at 6 and 24 h, respectively), confirming that the extract was not toxic. Maximum mortalities occurred at 100 mg/mL concentration while the least mortalities happened to be at 0.195 mg/mL concentration. The results of both tests confirm that E. guineensis is nontoxic and hence safe for commercial utilization.http://www.mdpi.com/1420-3049/15/11/8111/Elaeis guineensismethanol extractacute oral toxicitybrine shrimp lethality assay |
| spellingShingle | Yeng Chen Lai Ngit Shin Yee Ling Lau Sreenivasan Sasidharan Yuet Ping Kwan Lachimanan Yoga Latha Soundararajan Vijayarathna Abdul Rani Muhamad Syahmi Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract Molecules Elaeis guineensis methanol extract acute oral toxicity brine shrimp lethality assay |
| title | Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract |
| title_full | Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract |
| title_fullStr | Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract |
| title_full_unstemmed | Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract |
| title_short | Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract |
| title_sort | acute oral toxicity and brine shrimp lethality of elaeis guineensis jacq oil palm leaf methanol extract |
| topic | Elaeis guineensis methanol extract acute oral toxicity brine shrimp lethality assay |
| url | http://www.mdpi.com/1420-3049/15/11/8111/ |
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