The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon
PEGylated liposomes are potential candidates to improve the pharmacokinetic characteristics of encapsulated drugs, to extend their circulation half-life and facilitate their passive accumulation at tumour sites. However, PEG-modified liposomes can induce accelerated blood clearance (ABC) upon repeat...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-03-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087616300605 |
| _version_ | 1811230266940719104 |
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| author | Ting Zhang Songlei Zhou Le Kang Xiang Luo Yang Liu Yanzhi Song Xinrong Liu Yihui Deng |
| author_facet | Ting Zhang Songlei Zhou Le Kang Xiang Luo Yang Liu Yanzhi Song Xinrong Liu Yihui Deng |
| author_sort | Ting Zhang |
| collection | DOAJ |
| description | PEGylated liposomes are potential candidates to improve the pharmacokinetic characteristics of encapsulated drugs, to extend their circulation half-life and facilitate their passive accumulation at tumour sites. However, PEG-modified liposomes can induce accelerated blood clearance (ABC) upon repeated administration, and the extent of ABC phenomenon on the cytotoxic drugs-containing PEGylated liposomes is related to the dose of the cytotoxic drugs. In this study, EPI served as a model cytotoxic drug, a hydrophilic surfactant molecule, monosialylganglioside (GM1) was chosen and modified on the liposomes together with PEG. It was shown that upon mixed modification, when GM1 contents reached 10% or 15% mol, the ABC phenomenon of the PEGylated liposomal EPI significantly reduced. We also found that GM1 played an important role in abrogating the ABC phenomenon in both the induction phase and the effectuation phase. The results suggested that GM1 incorporation unfortunately did not avoid occurrence of ABC phenomenon completely, but GM1 modification on PEGylated liposomes may provide a significant improvement in clinical practice of PEGylated liposomes. Further study must be necessary. |
| first_indexed | 2024-04-12T10:26:45Z |
| format | Article |
| id | doaj.art-3173bb1578fe484e8a5867b69b0ce263 |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-04-12T10:26:45Z |
| publishDate | 2017-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-3173bb1578fe484e8a5867b69b0ce2632022-12-22T03:36:57ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762017-03-0112213414210.1016/j.ajps.2016.06.005The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenonTing ZhangSonglei ZhouLe KangXiang LuoYang LiuYanzhi SongXinrong LiuYihui DengPEGylated liposomes are potential candidates to improve the pharmacokinetic characteristics of encapsulated drugs, to extend their circulation half-life and facilitate their passive accumulation at tumour sites. However, PEG-modified liposomes can induce accelerated blood clearance (ABC) upon repeated administration, and the extent of ABC phenomenon on the cytotoxic drugs-containing PEGylated liposomes is related to the dose of the cytotoxic drugs. In this study, EPI served as a model cytotoxic drug, a hydrophilic surfactant molecule, monosialylganglioside (GM1) was chosen and modified on the liposomes together with PEG. It was shown that upon mixed modification, when GM1 contents reached 10% or 15% mol, the ABC phenomenon of the PEGylated liposomal EPI significantly reduced. We also found that GM1 played an important role in abrogating the ABC phenomenon in both the induction phase and the effectuation phase. The results suggested that GM1 incorporation unfortunately did not avoid occurrence of ABC phenomenon completely, but GM1 modification on PEGylated liposomes may provide a significant improvement in clinical practice of PEGylated liposomes. Further study must be necessary.http://www.sciencedirect.com/science/article/pii/S1818087616300605PEGylated liposomesEpirubicinMonosialylganglioside (GM1)Mixed modificationAccelerated blood clearance (ABC) phenomenon |
| spellingShingle | Ting Zhang Songlei Zhou Le Kang Xiang Luo Yang Liu Yanzhi Song Xinrong Liu Yihui Deng The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon Asian Journal of Pharmaceutical Sciences PEGylated liposomes Epirubicin Monosialylganglioside (GM1) Mixed modification Accelerated blood clearance (ABC) phenomenon |
| title | The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon |
| title_full | The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon |
| title_fullStr | The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon |
| title_full_unstemmed | The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon |
| title_short | The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon |
| title_sort | effect of monosialylganglioside mix modifying the pegylated liposomal epirubicin on the accelerated blood clearance phenomenon |
| topic | PEGylated liposomes Epirubicin Monosialylganglioside (GM1) Mixed modification Accelerated blood clearance (ABC) phenomenon |
| url | http://www.sciencedirect.com/science/article/pii/S1818087616300605 |
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