The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon

The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon

PEGylated liposomes are potential candidates to improve the pharmacokinetic characteristics of encapsulated drugs, to extend their circulation half-life and facilitate their passive accumulation at tumour sites. However, PEG-modified liposomes can induce accelerated blood clearance (ABC) upon repeat...

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Bibliographic Details
Main Authors: Ting Zhang, Songlei Zhou, Le Kang, Xiang Luo, Yang Liu, Yanzhi Song, Xinrong Liu, Yihui Deng
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
PEGylated liposomes
Epirubicin
Monosialylganglioside (GM1)
Mixed modification
Accelerated blood clearance (ABC) phenomenon
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616300605

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http://www.sciencedirect.com/science/article/pii/S1818087616300605

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