Sex features of cutaneous microvasculature in healthy working-age people
Aim. To study sex characteristics of cutaneous microvascular structure and function in a cohort of healthy working-age people without cardiovascular diseases.Material and methods. The study included 35 healthy men (42±4 years) and 34 women (41 ±5 years). The cardiovascular system was assessed in all...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2022-01-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3111 |
| _version_ | 1797882312842543104 |
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| author | K. V. Omelyanenko A. Yu. Gorshkov A. A. Fedorovich A. I. Korolev V. A. Dadaeva D. U. Akasheva O. M. Drapkina |
| author_facet | K. V. Omelyanenko A. Yu. Gorshkov A. A. Fedorovich A. I. Korolev V. A. Dadaeva D. U. Akasheva O. M. Drapkina |
| author_sort | K. V. Omelyanenko |
| collection | DOAJ |
| description | Aim. To study sex characteristics of cutaneous microvascular structure and function in a cohort of healthy working-age people without cardiovascular diseases.Material and methods. The study included 35 healthy men (42±4 years) and 34 women (41 ±5 years). The cardiovascular system was assessed in all patients. The microcirculatory bed of the skin was investigated by the following non-invasive methods: 1) computerized video capillaroscopy; 2) laser Doppler flowmetry; 3) photoplethysmography.Results. According to computerized video capillaroscopy in men, compared with women, there was a smaller number of both functioning capillaries (78 vs 86 capillaries/mm2, respectively (p<0,05)) and their total number (100 vs 120 capillaries/mm2, respectively (p<0,001)). Against the background of a decrease in capillary density in men, there was a higher skin interstitial hydration — 113 vs 96 gm (p<0,005) in men than in women. At the level of precapillary arterioles, where humoral tone regulation prevails. Laser Doppler flowmetry revealed lower pulse amplitude in men than in women — 0,87 vs 1,02 pf, respectively (p<0,05), which indicates a lower arterial blood inflow to exchange microvessels. Against this background, the constrictor response of precapillary arterioles to a sympathetic nervous system stimulation in men is higher than in women — 45% vs 40%, respectively (p<0,05). At the level of large arterioles, where neural tone regulation prevails, photoplethysmography revealed lower augmentation index standardized at a heart rate in men (-4,6 vs 1,7%, respectively, p<0,05), which indicates lower rigidity of muscular vessels in men.Conclusion. In working-age healthy people, sex differences are noted at all cutaneous microvascular levels, which must be taken into account when planning studies. |
| first_indexed | 2024-04-10T03:33:50Z |
| format | Article |
| id | doaj.art-31747d0ef0c34ed899b9df8864cb1299 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:33:50Z |
| publishDate | 2022-01-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
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| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-31747d0ef0c34ed899b9df8864cb12992023-03-13T07:23:32Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252022-01-0120810.15829/1728-8800-2021-31112411Sex features of cutaneous microvasculature in healthy working-age peopleK. V. Omelyanenko0A. Yu. Gorshkov1A. A. Fedorovich2A. I. Korolev3V. A. Dadaeva4D. U. Akasheva5O. M. Drapkina6ФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава России; ФГБУ ГНЦ РФ Институт медико-биологических проблем, РАНФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава России; ФГАОУ ВО Российский университет дружбы народовФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииФГБУ Национальный медицинский исследовательский центр терапии и профилактической медицины Минздрава РоссииAim. To study sex characteristics of cutaneous microvascular structure and function in a cohort of healthy working-age people without cardiovascular diseases.Material and methods. The study included 35 healthy men (42±4 years) and 34 women (41 ±5 years). The cardiovascular system was assessed in all patients. The microcirculatory bed of the skin was investigated by the following non-invasive methods: 1) computerized video capillaroscopy; 2) laser Doppler flowmetry; 3) photoplethysmography.Results. According to computerized video capillaroscopy in men, compared with women, there was a smaller number of both functioning capillaries (78 vs 86 capillaries/mm2, respectively (p<0,05)) and their total number (100 vs 120 capillaries/mm2, respectively (p<0,001)). Against the background of a decrease in capillary density in men, there was a higher skin interstitial hydration — 113 vs 96 gm (p<0,005) in men than in women. At the level of precapillary arterioles, where humoral tone regulation prevails. Laser Doppler flowmetry revealed lower pulse amplitude in men than in women — 0,87 vs 1,02 pf, respectively (p<0,05), which indicates a lower arterial blood inflow to exchange microvessels. Against this background, the constrictor response of precapillary arterioles to a sympathetic nervous system stimulation in men is higher than in women — 45% vs 40%, respectively (p<0,05). At the level of large arterioles, where neural tone regulation prevails, photoplethysmography revealed lower augmentation index standardized at a heart rate in men (-4,6 vs 1,7%, respectively, p<0,05), which indicates lower rigidity of muscular vessels in men.Conclusion. In working-age healthy people, sex differences are noted at all cutaneous microvascular levels, which must be taken into account when planning studies.https://cardiovascular.elpub.ru/jour/article/view/3111микроциркуляциявидеокапилляроскопиялазерная допплеровская флоуметрияфотоплетизмографиягендерные различияздоровые лица |
| spellingShingle | K. V. Omelyanenko A. Yu. Gorshkov A. A. Fedorovich A. I. Korolev V. A. Dadaeva D. U. Akasheva O. M. Drapkina Sex features of cutaneous microvasculature in healthy working-age people Кардиоваскулярная терапия и профилактика микроциркуляция видеокапилляроскопия лазерная допплеровская флоуметрия фотоплетизмография гендерные различия здоровые лица |
| title | Sex features of cutaneous microvasculature in healthy working-age people |
| title_full | Sex features of cutaneous microvasculature in healthy working-age people |
| title_fullStr | Sex features of cutaneous microvasculature in healthy working-age people |
| title_full_unstemmed | Sex features of cutaneous microvasculature in healthy working-age people |
| title_short | Sex features of cutaneous microvasculature in healthy working-age people |
| title_sort | sex features of cutaneous microvasculature in healthy working age people |
| topic | микроциркуляция видеокапилляроскопия лазерная допплеровская флоуметрия фотоплетизмография гендерные различия здоровые лица |
| url | https://cardiovascular.elpub.ru/jour/article/view/3111 |
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