Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in Italy
Background: The aims of the study were to determine, in the urine and oral samples of young adults, the genotype-specific prevalence of Human Papilloma Virus (HPV) infection, the HPV DNA type-specific prevalence in unvaccinated and vaccinated individuals, and the determinants of HPV infection. Metho...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/12/2/205 |
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| author | Francesco Napolitano Silvia Angelillo Aida Bianco Gabriella Di Giuseppe Valeria Di Onofrio Francesca Licata Giorgio Liguori Carmelo Giuseppe Angelo Nobile Maria Pavia Concetta Paola Pelullo Federica Zito Marino Italo Francesco Angelillo |
| author_facet | Francesco Napolitano Silvia Angelillo Aida Bianco Gabriella Di Giuseppe Valeria Di Onofrio Francesca Licata Giorgio Liguori Carmelo Giuseppe Angelo Nobile Maria Pavia Concetta Paola Pelullo Federica Zito Marino Italo Francesco Angelillo |
| author_sort | Francesco Napolitano |
| collection | DOAJ |
| description | Background: The aims of the study were to determine, in the urine and oral samples of young adults, the genotype-specific prevalence of Human Papilloma Virus (HPV) infection, the HPV DNA type-specific prevalence in unvaccinated and vaccinated individuals, and the determinants of HPV infection. Methods: Selected participants were asked to fill in a self-administered questionnaire and to self-collect urine and saliva samples. Results: Among the 1002 participants, 81 (8.1%) resulted positive for HPV DNA. The most common low-risk genotype was HPV 42 (2.2%), followed by HPV 43 (0.8%), and 40 (0.5%). The HPV 51 was the most common high-risk genotype (1.5%) followed by HPV 66 (1%) and HPV 68 (1%), and no participants were infected with HPV genotypes 18, 33, 45. Females, those who have had one or more occasional sexual partner, those who never/rarely/sometimes used condoms during their sexual activity, those with a previous diagnosis of sexually transmitted infection, and those who were not vaccinated were more likely to be tested positive for HPV infection. Conclusions: The low prevalence of genital HPV infections has provided evidence of the effectiveness of HPV vaccination both in vaccinated and not yet vaccinated subjects through herd immunity and indicated its decisive role in the changing epidemiology of circulating HPV genotypes in the population. |
| first_indexed | 2024-03-07T22:10:52Z |
| format | Article |
| id | doaj.art-31764eaa83154411b81e081dbd3d634c |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-07T22:10:52Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-31764eaa83154411b81e081dbd3d634c2024-02-23T15:37:10ZengMDPI AGVaccines2076-393X2024-02-0112220510.3390/vaccines12020205Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in ItalyFrancesco Napolitano0Silvia Angelillo1Aida Bianco2Gabriella Di Giuseppe3Valeria Di Onofrio4Francesca Licata5Giorgio Liguori6Carmelo Giuseppe Angelo Nobile7Maria Pavia8Concetta Paola Pelullo9Federica Zito Marino10Italo Francesco Angelillo11Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Sciences and Technologies, University of Naples “Parthenope”, 80143 Naples, ItalyDepartment of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, ItalyDepartment of Medical, Movement and Wellbeing Sciences, University of Naples “Parthenope”, 80133 Naples, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Cosenza, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medical, Movement and Wellbeing Sciences, University of Naples “Parthenope”, 80133 Naples, ItalyDepartment of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyBackground: The aims of the study were to determine, in the urine and oral samples of young adults, the genotype-specific prevalence of Human Papilloma Virus (HPV) infection, the HPV DNA type-specific prevalence in unvaccinated and vaccinated individuals, and the determinants of HPV infection. Methods: Selected participants were asked to fill in a self-administered questionnaire and to self-collect urine and saliva samples. Results: Among the 1002 participants, 81 (8.1%) resulted positive for HPV DNA. The most common low-risk genotype was HPV 42 (2.2%), followed by HPV 43 (0.8%), and 40 (0.5%). The HPV 51 was the most common high-risk genotype (1.5%) followed by HPV 66 (1%) and HPV 68 (1%), and no participants were infected with HPV genotypes 18, 33, 45. Females, those who have had one or more occasional sexual partner, those who never/rarely/sometimes used condoms during their sexual activity, those with a previous diagnosis of sexually transmitted infection, and those who were not vaccinated were more likely to be tested positive for HPV infection. Conclusions: The low prevalence of genital HPV infections has provided evidence of the effectiveness of HPV vaccination both in vaccinated and not yet vaccinated subjects through herd immunity and indicated its decisive role in the changing epidemiology of circulating HPV genotypes in the population.https://www.mdpi.com/2076-393X/12/2/205geno-prevalenceHPV vaccinationsalivaurineyoung adults |
| spellingShingle | Francesco Napolitano Silvia Angelillo Aida Bianco Gabriella Di Giuseppe Valeria Di Onofrio Francesca Licata Giorgio Liguori Carmelo Giuseppe Angelo Nobile Maria Pavia Concetta Paola Pelullo Federica Zito Marino Italo Francesco Angelillo Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in Italy Vaccines geno-prevalence HPV vaccination saliva urine young adults |
| title | Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in Italy |
| title_full | Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in Italy |
| title_fullStr | Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in Italy |
| title_full_unstemmed | Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in Italy |
| title_short | Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in Italy |
| title_sort | genital and oral hpv geno prevalence measured through urine and saliva samples in young adults in italy |
| topic | geno-prevalence HPV vaccination saliva urine young adults |
| url | https://www.mdpi.com/2076-393X/12/2/205 |
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