Control of the Autophagy Pathway in Osteoarthritis: Key Regulators, Therapeutic Targets and Therapeutic Strategies
Autophagy is involved in different degenerative diseases and it may control epigenetic modifications, metabolic processes, stem cells differentiation as well as apoptosis. Autophagy plays a key role in maintaining the homeostasis of cartilage, the tissue produced by chondrocytes; its impairment has...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/5/2700 |
| _version_ | 1797412622283309056 |
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| author | Maria Teresa Valenti Luca Dalle Carbonare Donato Zipeto Monica Mottes |
| author_facet | Maria Teresa Valenti Luca Dalle Carbonare Donato Zipeto Monica Mottes |
| author_sort | Maria Teresa Valenti |
| collection | DOAJ |
| description | Autophagy is involved in different degenerative diseases and it may control epigenetic modifications, metabolic processes, stem cells differentiation as well as apoptosis. Autophagy plays a key role in maintaining the homeostasis of cartilage, the tissue produced by chondrocytes; its impairment has been associated to cartilage dysfunctions such as osteoarthritis (OA). Due to their location in a reduced oxygen context, both differentiating and mature chondrocytes are at risk of premature apoptosis, which can be prevented by autophagy. AutophagomiRNAs, which regulate the autophagic process, have been found differentially expressed in OA. AutophagomiRNAs, as well as other regulatory molecules, may also be useful as therapeutic targets. In this review, we describe and discuss the role of autophagy in OA, focusing mainly on the control of autophagomiRNAs in OA pathogenesis and their potential therapeutic applications. |
| first_indexed | 2024-03-09T05:05:48Z |
| format | Article |
| id | doaj.art-3179ab8c058549c28adb29d5891ecd75 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:05:48Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3179ab8c058549c28adb29d5891ecd752023-12-03T12:54:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01225270010.3390/ijms22052700Control of the Autophagy Pathway in Osteoarthritis: Key Regulators, Therapeutic Targets and Therapeutic StrategiesMaria Teresa Valenti0Luca Dalle Carbonare1Donato Zipeto2Monica Mottes3Department of Medicine, Section of Internal Medicine, University of Verona, 37134 Verona, ItalyDepartment of Medicine, Section of Internal Medicine, University of Verona, 37134 Verona, ItalyDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, 37134 Verona, ItalyDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, 37134 Verona, ItalyAutophagy is involved in different degenerative diseases and it may control epigenetic modifications, metabolic processes, stem cells differentiation as well as apoptosis. Autophagy plays a key role in maintaining the homeostasis of cartilage, the tissue produced by chondrocytes; its impairment has been associated to cartilage dysfunctions such as osteoarthritis (OA). Due to their location in a reduced oxygen context, both differentiating and mature chondrocytes are at risk of premature apoptosis, which can be prevented by autophagy. AutophagomiRNAs, which regulate the autophagic process, have been found differentially expressed in OA. AutophagomiRNAs, as well as other regulatory molecules, may also be useful as therapeutic targets. In this review, we describe and discuss the role of autophagy in OA, focusing mainly on the control of autophagomiRNAs in OA pathogenesis and their potential therapeutic applications.https://www.mdpi.com/1422-0067/22/5/2700mesenchimal stem cellschondrocytic commitmentautophagyosteoarthritismiRNAs |
| spellingShingle | Maria Teresa Valenti Luca Dalle Carbonare Donato Zipeto Monica Mottes Control of the Autophagy Pathway in Osteoarthritis: Key Regulators, Therapeutic Targets and Therapeutic Strategies International Journal of Molecular Sciences mesenchimal stem cells chondrocytic commitment autophagy osteoarthritis miRNAs |
| title | Control of the Autophagy Pathway in Osteoarthritis: Key Regulators, Therapeutic Targets and Therapeutic Strategies |
| title_full | Control of the Autophagy Pathway in Osteoarthritis: Key Regulators, Therapeutic Targets and Therapeutic Strategies |
| title_fullStr | Control of the Autophagy Pathway in Osteoarthritis: Key Regulators, Therapeutic Targets and Therapeutic Strategies |
| title_full_unstemmed | Control of the Autophagy Pathway in Osteoarthritis: Key Regulators, Therapeutic Targets and Therapeutic Strategies |
| title_short | Control of the Autophagy Pathway in Osteoarthritis: Key Regulators, Therapeutic Targets and Therapeutic Strategies |
| title_sort | control of the autophagy pathway in osteoarthritis key regulators therapeutic targets and therapeutic strategies |
| topic | mesenchimal stem cells chondrocytic commitment autophagy osteoarthritis miRNAs |
| url | https://www.mdpi.com/1422-0067/22/5/2700 |
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