Identification of a Pharmacological Biomarker for the Bioassay-Based Quality Control of a Thirteen-Component TCM Formula (Lianhua Qingwen) Used in Treating Influenza A Virus (H1N1) Infection

Identification of a Pharmacological Biomarker for the Bioassay-Based Quality Control of a Thirteen-Component TCM Formula (Lianhua Qingwen) Used in Treating Influenza A Virus (H1N1) Infection

As chemical analysis for quality control (QC) of traditional Chinese medicine (TCM) formula is difficult to guarantee the effectiveness, a bioassay method that combines QC with evaluation of therapeutic effects has been developed to assess the TCM quality. Here, we chose a thirteen-component TCM for...

Full description

Bibliographic Details
Main Authors:	Dan Gao, Ming Niu, Shi-zhang Wei, Cong-en Zhang, Yong-feng Zhou, Zheng-wei Yang, Lin Li, Jia-bo Wang, Hai-zhu Zhang, Lan Zhang, Xiao-he Xiao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-05-01
Series:	Frontiers in Pharmacology
Subjects:	traditional Chinese medicine Lianhua Qingwen capsule influenza A virus (H1N1) pharmacological biomarker bioassay quality control
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00746/full

Similar Items

Screening for Anti-Inflammation Quality Markers of Lianhua Qingwen Capsule Based on Network Pharmacology, UPLC, and Biological Activity
by: Yongfeng Zhou, et al.
Published: (2021-06-01)

Predicting for anti-(mutant) SARS-CoV-2 and anti-inflammation compounds of Lianhua Qingwen Capsules in treating COVID-19
by: Liang Hong, et al.
Published: (2022-07-01)

Comprehensive characterization of the chemical constituents of Lianhua Qingwen capsule by ultra high performance liquid chromatography coupled with Fourier transform ion cyclotron resonance mass spectrometry
by: Ting Liu, et al.
Published: (2024-03-01)

A meta-analysis for Lianhua Qingwen on the treatment of Coronavirus disease 2019 (COVID-19)
by: Jieqin Zhuang, et al.
Published: (2021-08-01)

Efficacy and Safety of Chinese Medicine Lianhua Qingwen for Treating COVID-19: An Updated meta-Analysis
by: Yapeng Li, et al.
Published: (2022-06-01)

Qualitative analysis of chemical components in Lianhua Qingwen capsule by HPLC-Q Exactive-Orbitrap-MS coupled with GC-MS
by: Shuai Fu, et al.
Published: (2021-12-01)

Clinical applications and pharmacological research progress of Lianhua Qingwen capsules/granules
by: Zhenhua Jia, et al.
Published: (2021-04-01)

Mechanisms Underlying the Effects of Lianhua Qingwen on Sepsis-Induced Acute Lung Injury: A Network Pharmacology Approach
by: Ruhao Yang, et al.
Published: (2021-10-01)

The Adverse Reactions of Lianhua Qingwen Capsule/Granule Compared With Conventional Drug in Clinical Application: A Meta-Analysis
by: Caiyun Hu, et al.
Published: (2022-01-01)

Impact of Lianhua Qingwen on viral shedding in omicron mild/asymtomatic patients: a real-world study
by: Xiaoyan Gai, et al.
Published: (2024-03-01)

Molecular docking and molecular dynamics study Lianhua Qingwen granules (LHQW) treats COVID-19 by inhibiting inflammatory response and regulating cell survival
by: Jun-Feng Cao, et al.
Published: (2022-11-01)

Intestinal microbiota analysis and network pharmacology reveal the mechanism by which Lianhua Qingwen capsule improves the immune function of mice infected with influenza A virus
by: Ping Xu, et al.
Published: (2022-11-01)

The effects of Chinese proprietary medicine and vaccination on patients with COVID-19: a retrospective study in Macao
by: Hui Mo, et al.
Published: (2024-01-01)

Establishment of an anti-inflammation-based bioassay for the quality control of the 13-component TCM formula (Lianhua Qingwen)
by: Shuaishuai Chen, et al.
Published: (2021-01-01)

Efficacy and safety of Lianhua Qingwen granule in the treatment of non-influenza viral pneumonia: a randomized, double-blind, placebo-controlled, multicenter clinical study
by: Chengjie Ma, et al.
Published: (2024-01-01)

The clinical efficacy and safety research of Lianhuaqingwen (LHQW) in treatment of COVID-19: A systematic review and meta-analysis
by: Ling Fang, et al.
Published: (2022-06-01)

Bioactive Components from Qingwen Baidu Decoction against LPS-Induced Acute Lung Injury in Rats
by: Qi Zhang, et al.
Published: (2017-04-01)

Protective effects of ethyl gallate and pentagalloylglucose, the active components of Qingwen Baidu Decoction, against lipopolysaccharide-induced acute lung injury in rats
by: Zhang Q, et al.
Published: (2018-12-01)

Therapeutic potential of Lianhua Qingke in airway mucus hypersecretion of acute exacerbation of chronic obstructive pulmonary disease
by: Yuanjie Hao, et al.
Published: (2023-11-01)

Network pharmacology and computer-aided drug design to explored potential targets of Lianhua Qingwen and Qingfei Paidu decoction for COVID-19
by: Liyuan Li, et al.
Published: (2022-09-01)

Targeted Selecting of Bioassay Methods as an Alternative to the “Battery of Bioassays”
by: Anna Olkova
Published: (2022-03-01)

Electrogenerated chemiluminescence peptide-based bioassay
by: Qi Honglan, et al.
Published: (2014-12-01)

Brine shrimp : a convenient general bioassay for active plant constituents /
by: Meyer, B. N.

Quality Evaluation of Bioactive Ingredients in Lianhua Qingwen Capsule Based on Quantitative Analysis of Multicomponent by the Single Marker Method and the Chemical Recognition Patterns Method
by: Qianqian Zhou, et al.
Published: (2023-01-01)

WHO cone bioassay boards with or without holes: relevance for bioassay outcomes in long-lasting insecticidal net studies
by: Melanie Koinari, et al.
Published: (2022-12-01)

Recent Progress in Nucleic Acid Aptamer-Based Biosensors and Bioassays
by: Yingfu Li, et al.
Published: (2008-11-01)

Comparison of the variability in mortality data generated by CDC bottle bioassay, WHO tube test, and topical application bioassay using Aedes aegypti mosquitoes
by: Rachel A. Althoff, et al.
Published: (2022-12-01)

Brine shrimp bioassay procedure to determine produced water toxicity /
by: Wan Mohd. Haniff Wan Harun, 1991-, author 635223, et al.
Published: (2014)

Using a Battery of Bioassays to Assess the Toxicity of Wastewater Treatment Plant Effluents in Industrial Parks
by: Bin Yang, et al.
Published: (2023-08-01)

The application of bioassay techniques to water pollution problems - the United Kingdom experience /
by: 278217 Mackay, D. W., et al.

Traditional Chinese medicine Lianhua Qingwen treating corona virus disease 2019(COVID-19): Meta-analysis of randomized controlled trials
by: Mengjie Zeng, et al.
Published: (2020-01-01)

The procedure for selecting bioassays for different types of pollution
by: Anna S. Olkova
Published: (2022-09-01)

Brine shrimp bioassay procedure to determine produced water toxicity [electronic resource] /
by: Wan Mohd. Haniff Wan Harun, 1991-, author 635223, et al.
Published: (2014)

Comparison of in vitro and in vivo repellency bioassay methods for Ixodes scapularis nymphs
by: James C. Burtis, et al.
Published: (2023-07-01)

Rapid Sensing of Biological and Environmental Analytes Using Microwave-Accelerated Bioassays and a MATLAB Application
by: Enock Bonyi, et al.
Published: (2019-06-01)

Bioassay of natural products with special emphasis on anticancer agents : programme and abstracts /
by: National Seminar and Unesco Regional Workshop on Bioassay of Natural Products With Special Emphasis on Anticancer Agents (8th : 1991 : Kuala Lumpur), et al.
Published: (1991)

Analysis of the total toxicity of some technogenically disturbed soils using bioassays
by: Anh Van Ta Thi, et al.
Published: (2021-01-01)

Detection of Trypanosoma evansi in a naturally infected cat in Indonesia using bioassay and molecular techniques
by: Dwi Priyowidodo, et al.
Published: (2023-04-01)

Influence of Biofertilizers on Macronutrient uptake by the Mulberry Plant and its Impact on Silkworm Bioassay
by: Baqual, M.F., et al.
Published: (2006-04-01)

Comparison of CDC Bottle Bioassay with WHO Standard Method for Assessment Susceptibility Level of Malaria Vector, Anopheles stephensi to Three Imagicides
by: Hassan Vatandoost, et al.
Published: (2018-10-01)