Association between gut microbiota and its functional metabolites with prenatal depression in women
Background: The gut microbiota may affect mood through the microbiota-gut-brain axis. The purpose of this study was to examine the effect of the gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs), on prenatal depression and to determine the role of 5-hydroxytryptamine (5-HT)...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289523000802 |
| _version_ | 1797334720694976512 |
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| author | Tianqu Xie Xiaoxiao Fan Hanghang Pang Tianzi Zang Ni Wu Juan Liu Ziying Li Sha Li Quanfei Zhu Julia Elise Slack Jinbing Bai Yu Xu Yanqun Liu |
| author_facet | Tianqu Xie Xiaoxiao Fan Hanghang Pang Tianzi Zang Ni Wu Juan Liu Ziying Li Sha Li Quanfei Zhu Julia Elise Slack Jinbing Bai Yu Xu Yanqun Liu |
| author_sort | Tianqu Xie |
| collection | DOAJ |
| description | Background: The gut microbiota may affect mood through the microbiota-gut-brain axis. The purpose of this study was to examine the effect of the gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs), on prenatal depression and to determine the role of 5-hydroxytryptamine (5-HT) on prenatal depression in association with the gut microbiota and its metabolites (i.e. SCFAs). Methods: Eighty-six pregnant women in the third trimester were recruited. Prenatal depression was determined by a score of 10 via the Edinburgh Postpartum Depression Scale. Demographic data, stool, and blood samples were collected. The gut microbiota and its metabolites SCFAs were determined by 16S rRNA gene sequencing and liquid chromatography-mass spectrometry analysis. Plasma 5-HT was determined by gas chromatography-mass spectrometry analysis. Results: After controlling relevant covariates, our results found the higher the abundance of Candidatus_Soleaferrea, the lower the risk of prenatal depression; the higher the concentration of propanoic acid, the higher risk of prenatal depression. Our results also found the lower the plasma 5-HT, the higher the risk of prenatal depression, and 5-HT was related to unclassified_c_Clostridia and NK4A214_group. However, results of this study did not support the moderating effect of plasma 5-HT on the association of Candidatus_Soleaferrea or propionic acid with prenatal depression. Conclusions: Results of this study supported that changes in certain gut microbiota, SCFAs, and plasma 5-HT during pregnancy were associated with prenatal depression. This finding provides new ideas for interventions based on diet or probiotics to regulate mood during pregnancy. |
| first_indexed | 2024-03-08T08:26:17Z |
| format | Article |
| id | doaj.art-317b8df0dcc242128718480e5d3d449c |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-03-08T08:26:17Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-317b8df0dcc242128718480e5d3d449c2024-02-02T04:39:32ZengElsevierNeurobiology of Stress2352-28952024-01-0128100592Association between gut microbiota and its functional metabolites with prenatal depression in womenTianqu Xie0Xiaoxiao Fan1Hanghang Pang2Tianzi Zang3Ni Wu4Juan Liu5Ziying Li6Sha Li7Quanfei Zhu8Julia Elise Slack9Jinbing Bai10Yu Xu11Yanqun Liu12Center for Women and Children Health and Metabolism Research, School of Nursing, Wuhan University, 169 Donghu Road, Wuhan, 430071, ChinaCenter for Women and Children Health and Metabolism Research, School of Nursing, Wuhan University, 169 Donghu Road, Wuhan, 430071, ChinaCenter for Women and Children Health and Metabolism Research, School of Nursing, Wuhan University, 169 Donghu Road, Wuhan, 430071, China; Huaihe Hospital of Henan University, 475000, ChinaCenter for Women and Children Health and Metabolism Research, School of Nursing, Wuhan University, 169 Donghu Road, Wuhan, 430071, ChinaCenter for Women and Children Health and Metabolism Research, School of Nursing, Wuhan University, 169 Donghu Road, Wuhan, 430071, ChinaDepartment of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, 430071, ChinaDepartment of Chemistry, Wuhan University, Wuhan, 430072, ChinaDepartment of Chemistry, Wuhan University, Wuhan, 430072, ChinaSchool of Public Health, Wuhan University, Wuhan, 430071, ChinaEmory University Nell Hodgson Woodruff School of Nursing, 1520 Clifton Road, Atlanta, GA, 30322, USAEmory University Nell Hodgson Woodruff School of Nursing, 1520 Clifton Road, Atlanta, GA, 30322, USADepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Corresponding author.Center for Women and Children Health and Metabolism Research, School of Nursing, Wuhan University, 169 Donghu Road, Wuhan, 430071, China; Corresponding author. Cencer for Women and Children Health and Metabolism Research, School of Nursing, Wuhan University, 169 Donghu Road, Wuhan, 430071, China.Background: The gut microbiota may affect mood through the microbiota-gut-brain axis. The purpose of this study was to examine the effect of the gut microbiota and its metabolites, such as short-chain fatty acids (SCFAs), on prenatal depression and to determine the role of 5-hydroxytryptamine (5-HT) on prenatal depression in association with the gut microbiota and its metabolites (i.e. SCFAs). Methods: Eighty-six pregnant women in the third trimester were recruited. Prenatal depression was determined by a score of 10 via the Edinburgh Postpartum Depression Scale. Demographic data, stool, and blood samples were collected. The gut microbiota and its metabolites SCFAs were determined by 16S rRNA gene sequencing and liquid chromatography-mass spectrometry analysis. Plasma 5-HT was determined by gas chromatography-mass spectrometry analysis. Results: After controlling relevant covariates, our results found the higher the abundance of Candidatus_Soleaferrea, the lower the risk of prenatal depression; the higher the concentration of propanoic acid, the higher risk of prenatal depression. Our results also found the lower the plasma 5-HT, the higher the risk of prenatal depression, and 5-HT was related to unclassified_c_Clostridia and NK4A214_group. However, results of this study did not support the moderating effect of plasma 5-HT on the association of Candidatus_Soleaferrea or propionic acid with prenatal depression. Conclusions: Results of this study supported that changes in certain gut microbiota, SCFAs, and plasma 5-HT during pregnancy were associated with prenatal depression. This finding provides new ideas for interventions based on diet or probiotics to regulate mood during pregnancy.http://www.sciencedirect.com/science/article/pii/S2352289523000802Prenatal depression5-HydroxytryptamineGut microbiotaMicrobiota-gut-brain axisShort chain fatty acids |
| spellingShingle | Tianqu Xie Xiaoxiao Fan Hanghang Pang Tianzi Zang Ni Wu Juan Liu Ziying Li Sha Li Quanfei Zhu Julia Elise Slack Jinbing Bai Yu Xu Yanqun Liu Association between gut microbiota and its functional metabolites with prenatal depression in women Neurobiology of Stress Prenatal depression 5-Hydroxytryptamine Gut microbiota Microbiota-gut-brain axis Short chain fatty acids |
| title | Association between gut microbiota and its functional metabolites with prenatal depression in women |
| title_full | Association between gut microbiota and its functional metabolites with prenatal depression in women |
| title_fullStr | Association between gut microbiota and its functional metabolites with prenatal depression in women |
| title_full_unstemmed | Association between gut microbiota and its functional metabolites with prenatal depression in women |
| title_short | Association between gut microbiota and its functional metabolites with prenatal depression in women |
| title_sort | association between gut microbiota and its functional metabolites with prenatal depression in women |
| topic | Prenatal depression 5-Hydroxytryptamine Gut microbiota Microbiota-gut-brain axis Short chain fatty acids |
| url | http://www.sciencedirect.com/science/article/pii/S2352289523000802 |
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