Metastasis of ovarian cancer to nasal skin and skin on the trunk: a rare case report
Cutaneous metastases of ovarian cancer are rare and often have poor prognosis. We report a case of a 62-year-old woman with recurrent low-grade serous ovarian cancer, who presented with lung, brain, and multiple skin (nasal and anterior chest wall) metastases approximately six months after the initi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1266820/full |
| _version_ | 1797657241375997952 |
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| author | Chen Chen Ouyang Yingyao Xiang Yan He Qianru He Qianru He Qianru Wang Hong Chen Chen Yang Lei |
| author_facet | Chen Chen Ouyang Yingyao Xiang Yan He Qianru He Qianru He Qianru Wang Hong Chen Chen Yang Lei |
| author_sort | Chen Chen |
| collection | DOAJ |
| description | Cutaneous metastases of ovarian cancer are rare and often have poor prognosis. We report a case of a 62-year-old woman with recurrent low-grade serous ovarian cancer, who presented with lung, brain, and multiple skin (nasal and anterior chest wall) metastases approximately six months after the initial diagnosis. In this case, Nijmegen breakage syndrome carrier status caused by RAD50 heterozygous mutation and previous bevacizumab therapy could be the predisposing factor for cutaneous metastases. The patient was treated with local radiotherapy (nasal skin and brain, 30Gy/6f/1.2W) and three courses of chemotherapy with albumin-bound paclitaxel and carboplatin, resulting in drastic remission of the cutaneous metastases. Unfortunately, treatment interruption resulted in rapid tumor progression, followed by death. This case represents an interesting example of cutaneous metastasis of ovarian cancer with rare clinical manifestations, unique genetic mutations, and reasonable response to treatment. Chemoradiotherapy might be an appropriate option for cutaneous metastases of ovarian cancer. Nevertheless, we still hope to find out the best treatment strategy after collecting and reviewing more cases in the future. |
| first_indexed | 2024-03-11T17:41:41Z |
| format | Article |
| id | doaj.art-317e23db5495427881c09b0437d7173f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T17:41:41Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-317e23db5495427881c09b0437d7173f2023-10-18T09:25:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-10-011310.3389/fonc.2023.12668201266820Metastasis of ovarian cancer to nasal skin and skin on the trunk: a rare case reportChen Chen0Ouyang Yingyao1Xiang Yan2He Qianru3He Qianru4He Qianru5Wang Hong6Chen Chen7Yang Lei8Department of Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaThe Medical Department, Jiangsu Simcere Diagnostics Co., Ltd, Nanjing, ChinaNanjing Simcere Medical Laboratory Science Co., Ltd, Nanjing, ChinaThe State Key Laboratory of Translational Medicine and Innovative Drug Development, Jiangsu Simcere Diagnostics Co., Ltd, Nanjing, ChinaDepartment of Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaDepartment of Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, ChinaCutaneous metastases of ovarian cancer are rare and often have poor prognosis. We report a case of a 62-year-old woman with recurrent low-grade serous ovarian cancer, who presented with lung, brain, and multiple skin (nasal and anterior chest wall) metastases approximately six months after the initial diagnosis. In this case, Nijmegen breakage syndrome carrier status caused by RAD50 heterozygous mutation and previous bevacizumab therapy could be the predisposing factor for cutaneous metastases. The patient was treated with local radiotherapy (nasal skin and brain, 30Gy/6f/1.2W) and three courses of chemotherapy with albumin-bound paclitaxel and carboplatin, resulting in drastic remission of the cutaneous metastases. Unfortunately, treatment interruption resulted in rapid tumor progression, followed by death. This case represents an interesting example of cutaneous metastasis of ovarian cancer with rare clinical manifestations, unique genetic mutations, and reasonable response to treatment. Chemoradiotherapy might be an appropriate option for cutaneous metastases of ovarian cancer. Nevertheless, we still hope to find out the best treatment strategy after collecting and reviewing more cases in the future.https://www.frontiersin.org/articles/10.3389/fonc.2023.1266820/fullcutaneous metastasesneoplasm metastasisovarian cancerskin metastasestreatment |
| spellingShingle | Chen Chen Ouyang Yingyao Xiang Yan He Qianru He Qianru He Qianru Wang Hong Chen Chen Yang Lei Metastasis of ovarian cancer to nasal skin and skin on the trunk: a rare case report Frontiers in Oncology cutaneous metastases neoplasm metastasis ovarian cancer skin metastases treatment |
| title | Metastasis of ovarian cancer to nasal skin and skin on the trunk: a rare case report |
| title_full | Metastasis of ovarian cancer to nasal skin and skin on the trunk: a rare case report |
| title_fullStr | Metastasis of ovarian cancer to nasal skin and skin on the trunk: a rare case report |
| title_full_unstemmed | Metastasis of ovarian cancer to nasal skin and skin on the trunk: a rare case report |
| title_short | Metastasis of ovarian cancer to nasal skin and skin on the trunk: a rare case report |
| title_sort | metastasis of ovarian cancer to nasal skin and skin on the trunk a rare case report |
| topic | cutaneous metastases neoplasm metastasis ovarian cancer skin metastases treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1266820/full |
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