Antiparkinsonian medication masks motor signal progression in de novo patients
Patients not yet receiving medication provide insight to drug-naïve early physiology of Parkinson's Disease (PD). Wearable sensors can measure changes in motor features before and after introduction of antiparkinsonian medication. We aimed to identify features of upper limb bradykinesia, postur...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023036228 |
| _version_ | 1827941611993038848 |
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| author | Maksymilian A. Brzezicki Niall Conway Charalampos Sotirakis James J. FitzGerald Chrystalina A. Antoniades |
| author_facet | Maksymilian A. Brzezicki Niall Conway Charalampos Sotirakis James J. FitzGerald Chrystalina A. Antoniades |
| author_sort | Maksymilian A. Brzezicki |
| collection | DOAJ |
| description | Patients not yet receiving medication provide insight to drug-naïve early physiology of Parkinson's Disease (PD). Wearable sensors can measure changes in motor features before and after introduction of antiparkinsonian medication. We aimed to identify features of upper limb bradykinesia, postural stability, and gait that measurably progress in de novo PD patients prior to the start of medication, and determine whether these features remain sensitive to progression in the period after commencement of antiparkinsonian medication.Upper limb motion was measured using an inertial sensor worn on a finger, while postural stability and gait were recorded using an array of six wearable sensors. Patients were tested over nine visits at three monthly intervals. The timepoint of start of medication was noted.Three upper limb bradykinetic features (finger tapping speed, pronation supination speed, and pronation supination amplitude) and three gait features (gait speed, arm range of motion, duration of stance phase) were found to progress in unmedicated early-stage PD patients. In all features, progression was masked after the start of medication.Commencing antiparkinsonian medication is known to lead to masking of progression signals in clinical measures in de novo PD patients. In this study, we show that this effect is also observed with digital measures of bradykinetic and gait motor features. |
| first_indexed | 2024-03-13T09:41:18Z |
| format | Article |
| id | doaj.art-317e68fb2cce48e0b4d5bdb4c50dbb0f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T09:41:18Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-317e68fb2cce48e0b4d5bdb4c50dbb0f2023-05-25T04:24:42ZengElsevierHeliyon2405-84402023-06-0196e16415Antiparkinsonian medication masks motor signal progression in de novo patientsMaksymilian A. Brzezicki0Niall Conway1Charalampos Sotirakis2James J. FitzGerald3Chrystalina A. Antoniades4Neurometrology Lab, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UKNeurometrology Lab, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UKNeurometrology Lab, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UKNeurometrology Lab, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UKNeurometrology Lab, Nuffield Department of Clinical Neurosciences, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK; Corresponding author. Nuffield Department of Clinical Neurosciences, Level 6, West Wing, John Radcliffe Hospital, University of Oxford, United Kingdom.Patients not yet receiving medication provide insight to drug-naïve early physiology of Parkinson's Disease (PD). Wearable sensors can measure changes in motor features before and after introduction of antiparkinsonian medication. We aimed to identify features of upper limb bradykinesia, postural stability, and gait that measurably progress in de novo PD patients prior to the start of medication, and determine whether these features remain sensitive to progression in the period after commencement of antiparkinsonian medication.Upper limb motion was measured using an inertial sensor worn on a finger, while postural stability and gait were recorded using an array of six wearable sensors. Patients were tested over nine visits at three monthly intervals. The timepoint of start of medication was noted.Three upper limb bradykinetic features (finger tapping speed, pronation supination speed, and pronation supination amplitude) and three gait features (gait speed, arm range of motion, duration of stance phase) were found to progress in unmedicated early-stage PD patients. In all features, progression was masked after the start of medication.Commencing antiparkinsonian medication is known to lead to masking of progression signals in clinical measures in de novo PD patients. In this study, we show that this effect is also observed with digital measures of bradykinetic and gait motor features.http://www.sciencedirect.com/science/article/pii/S2405844023036228Parkinson'sMotor signalMedicationDenovoAccelerometers |
| spellingShingle | Maksymilian A. Brzezicki Niall Conway Charalampos Sotirakis James J. FitzGerald Chrystalina A. Antoniades Antiparkinsonian medication masks motor signal progression in de novo patients Heliyon Parkinson's Motor signal Medication Denovo Accelerometers |
| title | Antiparkinsonian medication masks motor signal progression in de novo patients |
| title_full | Antiparkinsonian medication masks motor signal progression in de novo patients |
| title_fullStr | Antiparkinsonian medication masks motor signal progression in de novo patients |
| title_full_unstemmed | Antiparkinsonian medication masks motor signal progression in de novo patients |
| title_short | Antiparkinsonian medication masks motor signal progression in de novo patients |
| title_sort | antiparkinsonian medication masks motor signal progression in de novo patients |
| topic | Parkinson's Motor signal Medication Denovo Accelerometers |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023036228 |
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