The effect on blink frequency of a selective blue-filtering photochromic lens in patients with benign essential blepharospasm
ObjectiveThe aim of this clinical study was to assess the impact of a non-invasive selective blue-filtering photochromic lens coating Crizal Prevencia on the treatment and response of benign essential blepharospasm (BEB).Patients and methodsTwenty-four patients were recruited in the outpatient clini...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1301947/full |
| _version_ | 1797387043522740224 |
|---|---|
| author | Tobias Monschein Tobias Monschein Tobias Zrzavy Tobias Zrzavy Corinna Weber Zoya Kuzmina Walter Gutstein Thomas Sycha Thomas Sycha |
| author_facet | Tobias Monschein Tobias Monschein Tobias Zrzavy Tobias Zrzavy Corinna Weber Zoya Kuzmina Walter Gutstein Thomas Sycha Thomas Sycha |
| author_sort | Tobias Monschein |
| collection | DOAJ |
| description | ObjectiveThe aim of this clinical study was to assess the impact of a non-invasive selective blue-filtering photochromic lens coating Crizal Prevencia on the treatment and response of benign essential blepharospasm (BEB).Patients and methodsTwenty-four patients were recruited in the outpatient clinic of the Medical University of Vienna in a randomized, double-blind, cross-over study design. Blink frequencies were assessed in patients with BEB before and 14 days after intervention with either a filtering ophthalmic lens or a placebo lens, respectively. Outcome parameters include sub-group analysis of a blink frequency under six different conditions: three photopic conditions, one resting condition, one reading condition, and one video game condition.ResultsFrom 24 recruited patients, 15 patients were available for final analysis. Comparing the optical blue filtering lens to placebo, showed a reduced blink frequency in specific subtests, but not compared to baseline.DiscussionIn conclusion, optical filtering glasses might have a beneficial effect on BEB and provide a non-invasive therapeutic add-on option, in addition to botulinum neurotoxin therapy, for patients with BEB and should necessarily be further investigated in a multicenter setting, resulting in larger sample sizes to gain valid information about the effect of photochromic blue filter glasses in BEB.Clinical trial registration: https://drks.de/search/en/trial/DRKS00032135, DRKS00032135. |
| first_indexed | 2024-03-08T22:18:05Z |
| format | Article |
| id | doaj.art-317eebcda5fb457a82d57cf3d198c633 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-08T22:18:05Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-317eebcda5fb457a82d57cf3d198c6332023-12-18T17:01:12ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-12-011410.3389/fneur.2023.13019471301947The effect on blink frequency of a selective blue-filtering photochromic lens in patients with benign essential blepharospasmTobias Monschein0Tobias Monschein1Tobias Zrzavy2Tobias Zrzavy3Corinna Weber4Zoya Kuzmina5Walter Gutstein6Thomas Sycha7Thomas Sycha8Department of Neurology, Medical University of Vienna, Vienna, AustriaComprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, AustriaDepartment of Neurology, Medical University of Vienna, Vienna, AustriaComprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, AustriaDepartment of Neurology, Medical University of Vienna, Vienna, AustriaAustrian Healthcare Center, Vienna, AustriaOHI – Optometry & Hearing Aid Initiative, Vienna, AustriaDepartment of Neurology, Medical University of Vienna, Vienna, AustriaComprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna, AustriaObjectiveThe aim of this clinical study was to assess the impact of a non-invasive selective blue-filtering photochromic lens coating Crizal Prevencia on the treatment and response of benign essential blepharospasm (BEB).Patients and methodsTwenty-four patients were recruited in the outpatient clinic of the Medical University of Vienna in a randomized, double-blind, cross-over study design. Blink frequencies were assessed in patients with BEB before and 14 days after intervention with either a filtering ophthalmic lens or a placebo lens, respectively. Outcome parameters include sub-group analysis of a blink frequency under six different conditions: three photopic conditions, one resting condition, one reading condition, and one video game condition.ResultsFrom 24 recruited patients, 15 patients were available for final analysis. Comparing the optical blue filtering lens to placebo, showed a reduced blink frequency in specific subtests, but not compared to baseline.DiscussionIn conclusion, optical filtering glasses might have a beneficial effect on BEB and provide a non-invasive therapeutic add-on option, in addition to botulinum neurotoxin therapy, for patients with BEB and should necessarily be further investigated in a multicenter setting, resulting in larger sample sizes to gain valid information about the effect of photochromic blue filter glasses in BEB.Clinical trial registration: https://drks.de/search/en/trial/DRKS00032135, DRKS00032135.https://www.frontiersin.org/articles/10.3389/fneur.2023.1301947/fullfocal dystoniablepharospasmBEBblue filterlens |
| spellingShingle | Tobias Monschein Tobias Monschein Tobias Zrzavy Tobias Zrzavy Corinna Weber Zoya Kuzmina Walter Gutstein Thomas Sycha Thomas Sycha The effect on blink frequency of a selective blue-filtering photochromic lens in patients with benign essential blepharospasm Frontiers in Neurology focal dystonia blepharospasm BEB blue filter lens |
| title | The effect on blink frequency of a selective blue-filtering photochromic lens in patients with benign essential blepharospasm |
| title_full | The effect on blink frequency of a selective blue-filtering photochromic lens in patients with benign essential blepharospasm |
| title_fullStr | The effect on blink frequency of a selective blue-filtering photochromic lens in patients with benign essential blepharospasm |
| title_full_unstemmed | The effect on blink frequency of a selective blue-filtering photochromic lens in patients with benign essential blepharospasm |
| title_short | The effect on blink frequency of a selective blue-filtering photochromic lens in patients with benign essential blepharospasm |
| title_sort | effect on blink frequency of a selective blue filtering photochromic lens in patients with benign essential blepharospasm |
| topic | focal dystonia blepharospasm BEB blue filter lens |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1301947/full |
| work_keys_str_mv | AT tobiasmonschein theeffectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT tobiasmonschein theeffectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT tobiaszrzavy theeffectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT tobiaszrzavy theeffectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT corinnaweber theeffectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT zoyakuzmina theeffectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT waltergutstein theeffectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT thomassycha theeffectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT thomassycha theeffectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT tobiasmonschein effectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT tobiasmonschein effectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT tobiaszrzavy effectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT tobiaszrzavy effectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT corinnaweber effectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT zoyakuzmina effectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT waltergutstein effectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT thomassycha effectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm AT thomassycha effectonblinkfrequencyofaselectivebluefilteringphotochromiclensinpatientswithbenignessentialblepharospasm |