Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases
Neuroinflammation, a pivotal factor in the pathogenesis of various brain disorders, including neurodegenerative diseases, has become a focal point for therapeutic exploration. This review highlights neuroinflammatory mechanisms that hallmark neurodegenerative diseases and the potential benefits of e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/2/178 |
| _version_ | 1797299079743537152 |
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| author | Rosanna Avola Alessandro Giuseppe Furnari Adriana Carol Eleonora Graziano Alessandra Russo Venera Cardile |
| author_facet | Rosanna Avola Alessandro Giuseppe Furnari Adriana Carol Eleonora Graziano Alessandra Russo Venera Cardile |
| author_sort | Rosanna Avola |
| collection | DOAJ |
| description | Neuroinflammation, a pivotal factor in the pathogenesis of various brain disorders, including neurodegenerative diseases, has become a focal point for therapeutic exploration. This review highlights neuroinflammatory mechanisms that hallmark neurodegenerative diseases and the potential benefits of essential oils in counteracting neuroinflammation and oxidative stress, thereby offering a novel strategy for managing and mitigating the impact of various brain disorders. Essential oils, derived from aromatic plants, have emerged as versatile compounds with a myriad of health benefits. Essential oils exhibit robust antioxidant activity, serving as scavengers of free radicals and contributing to cellular defense against oxidative stress. Furthermore, essential oils showcase anti-inflammatory properties, modulating immune responses and mitigating inflammatory processes implicated in various chronic diseases. The intricate mechanisms by which essential oils and phytomolecules exert their anti-inflammatory and antioxidant effects were explored, shedding light on their multifaceted properties. Notably, we discussed their ability to modulate diverse pathways crucial in maintaining oxidative homeostasis and suppressing inflammatory responses, and their capacity to rescue cognitive deficits observed in preclinical models of neurotoxicity and neurodegenerative diseases. |
| first_indexed | 2024-03-07T22:44:22Z |
| format | Article |
| id | doaj.art-3180c4065852466f971a94ec0c8d49cb |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-07T22:44:22Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-3180c4065852466f971a94ec0c8d49cb2024-02-23T15:05:24ZengMDPI AGAntioxidants2076-39212024-01-0113217810.3390/antiox13020178Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative DiseasesRosanna Avola0Alessandro Giuseppe Furnari1Adriana Carol Eleonora Graziano2Alessandra Russo3Venera Cardile4Faculty of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyFaculty of Medicine and Surgery, University of Enna “Kore”, 94100 Enna, ItalyDepartment of Drug and Health Sciences, University of Catania, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyNeuroinflammation, a pivotal factor in the pathogenesis of various brain disorders, including neurodegenerative diseases, has become a focal point for therapeutic exploration. This review highlights neuroinflammatory mechanisms that hallmark neurodegenerative diseases and the potential benefits of essential oils in counteracting neuroinflammation and oxidative stress, thereby offering a novel strategy for managing and mitigating the impact of various brain disorders. Essential oils, derived from aromatic plants, have emerged as versatile compounds with a myriad of health benefits. Essential oils exhibit robust antioxidant activity, serving as scavengers of free radicals and contributing to cellular defense against oxidative stress. Furthermore, essential oils showcase anti-inflammatory properties, modulating immune responses and mitigating inflammatory processes implicated in various chronic diseases. The intricate mechanisms by which essential oils and phytomolecules exert their anti-inflammatory and antioxidant effects were explored, shedding light on their multifaceted properties. Notably, we discussed their ability to modulate diverse pathways crucial in maintaining oxidative homeostasis and suppressing inflammatory responses, and their capacity to rescue cognitive deficits observed in preclinical models of neurotoxicity and neurodegenerative diseases.https://www.mdpi.com/2076-3921/13/2/178neuroinflammationoxidative stressessential oilsnatural compoundsneurodegenerative diseasesantioxidants |
| spellingShingle | Rosanna Avola Alessandro Giuseppe Furnari Adriana Carol Eleonora Graziano Alessandra Russo Venera Cardile Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases Antioxidants neuroinflammation oxidative stress essential oils natural compounds neurodegenerative diseases antioxidants |
| title | Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases |
| title_full | Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases |
| title_fullStr | Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases |
| title_full_unstemmed | Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases |
| title_short | Management of the Brain: Essential Oils as Promising Neuroinflammation Modulator in Neurodegenerative Diseases |
| title_sort | management of the brain essential oils as promising neuroinflammation modulator in neurodegenerative diseases |
| topic | neuroinflammation oxidative stress essential oils natural compounds neurodegenerative diseases antioxidants |
| url | https://www.mdpi.com/2076-3921/13/2/178 |
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