Multi-functional conductive hydrogels based on heparin–polydopamine complex reduced graphene oxide for epidermal sensing and chronic wound healing
Abstract Flexible hydrogel sensors have expanded the applications of electronic devices due to their suitable mechanical properties and excellent biocompatibility. However, conventionally synthesized reduced graphene oxide (rGO) encounters limitations in reduction degree and dispersion, restricting...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-02113-9 |
| _version_ | 1827633248744767488 |
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| author | Yiyong Dou Yuwei Zhang Shuo Zhang Shuo Ma Hong Zhang |
| author_facet | Yiyong Dou Yuwei Zhang Shuo Zhang Shuo Ma Hong Zhang |
| author_sort | Yiyong Dou |
| collection | DOAJ |
| description | Abstract Flexible hydrogel sensors have expanded the applications of electronic devices due to their suitable mechanical properties and excellent biocompatibility. However, conventionally synthesized reduced graphene oxide (rGO) encounters limitations in reduction degree and dispersion, restricting the conductivity of graphene hydrogels and impeding the development of high-sensitivity flexible sensors. Moreover, hydrogels are susceptible to inflammation and bacterial infections, jeopardizing sensor stability over time. Thus, the challenge persists in designing conductive hydrogels that encompass high sensitivity, antibacterial efficacy, and anti-oxidative capabilities. In this study, GO was modified and reduced via a heparin-polydopamine (Hep-PDA) complex, yielding well-reduced and uniformly dispersed Hep-PDA-rGO nanosheets. Consequently, a hydrogel utilizing Hep-PDA-rGO was synthesized, showcasing commendable conductivity (3.63 S/m) and sensor performance, effectively applied in real-time motion monitoring. Notably, the hydrogel’s attributes extend to facilitating chronic diabetic wound healing. It maintained a suitable inflammatory environment credited to its potent antibacterial and antioxidative properties, while its inherent conductivity promoted angiogenesis. The multifunctional nature of this hydrogel highlight its potential not only as an epidermal sensor but also as a promising dressing candidate for chronic wound treatment. |
| first_indexed | 2024-03-09T14:56:55Z |
| format | Article |
| id | doaj.art-318411566d8d4f79b024d4e93b427b4f |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-09T14:56:55Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-318411566d8d4f79b024d4e93b427b4f2023-11-26T14:08:26ZengBMCJournal of Nanobiotechnology1477-31552023-09-0121111510.1186/s12951-023-02113-9Multi-functional conductive hydrogels based on heparin–polydopamine complex reduced graphene oxide for epidermal sensing and chronic wound healingYiyong Dou0Yuwei Zhang1Shuo Zhang2Shuo Ma3Hong Zhang4Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan UniversityKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan UniversityKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan UniversityKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan UniversityKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan UniversityAbstract Flexible hydrogel sensors have expanded the applications of electronic devices due to their suitable mechanical properties and excellent biocompatibility. However, conventionally synthesized reduced graphene oxide (rGO) encounters limitations in reduction degree and dispersion, restricting the conductivity of graphene hydrogels and impeding the development of high-sensitivity flexible sensors. Moreover, hydrogels are susceptible to inflammation and bacterial infections, jeopardizing sensor stability over time. Thus, the challenge persists in designing conductive hydrogels that encompass high sensitivity, antibacterial efficacy, and anti-oxidative capabilities. In this study, GO was modified and reduced via a heparin-polydopamine (Hep-PDA) complex, yielding well-reduced and uniformly dispersed Hep-PDA-rGO nanosheets. Consequently, a hydrogel utilizing Hep-PDA-rGO was synthesized, showcasing commendable conductivity (3.63 S/m) and sensor performance, effectively applied in real-time motion monitoring. Notably, the hydrogel’s attributes extend to facilitating chronic diabetic wound healing. It maintained a suitable inflammatory environment credited to its potent antibacterial and antioxidative properties, while its inherent conductivity promoted angiogenesis. The multifunctional nature of this hydrogel highlight its potential not only as an epidermal sensor but also as a promising dressing candidate for chronic wound treatment.https://doi.org/10.1186/s12951-023-02113-9Reduced graphene oxideFlexible hydrogel sensorAntibacterialAnti-oxidativeChronic wound healing |
| spellingShingle | Yiyong Dou Yuwei Zhang Shuo Zhang Shuo Ma Hong Zhang Multi-functional conductive hydrogels based on heparin–polydopamine complex reduced graphene oxide for epidermal sensing and chronic wound healing Journal of Nanobiotechnology Reduced graphene oxide Flexible hydrogel sensor Antibacterial Anti-oxidative Chronic wound healing |
| title | Multi-functional conductive hydrogels based on heparin–polydopamine complex reduced graphene oxide for epidermal sensing and chronic wound healing |
| title_full | Multi-functional conductive hydrogels based on heparin–polydopamine complex reduced graphene oxide for epidermal sensing and chronic wound healing |
| title_fullStr | Multi-functional conductive hydrogels based on heparin–polydopamine complex reduced graphene oxide for epidermal sensing and chronic wound healing |
| title_full_unstemmed | Multi-functional conductive hydrogels based on heparin–polydopamine complex reduced graphene oxide for epidermal sensing and chronic wound healing |
| title_short | Multi-functional conductive hydrogels based on heparin–polydopamine complex reduced graphene oxide for epidermal sensing and chronic wound healing |
| title_sort | multi functional conductive hydrogels based on heparin polydopamine complex reduced graphene oxide for epidermal sensing and chronic wound healing |
| topic | Reduced graphene oxide Flexible hydrogel sensor Antibacterial Anti-oxidative Chronic wound healing |
| url | https://doi.org/10.1186/s12951-023-02113-9 |
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