Structural analysis of PpSP15 and PsSP9 sand fly salivary proteins designed with a self-cleavable linker as a live vaccine candidate against cutaneous leishmaniasis

Structural analysis of PpSP15 and PsSP9 sand fly salivary proteins designed with a self-cleavable linker as a live vaccine candidate against cutaneous leishmaniasis

Abstract Background Leishmania parasites are deposited in the host through sand fly bites along with sand fly saliva. Therefore, salivary proteins are promising vaccine candidates for controlling leishmaniasis. Herein, two immunogenic salivary proteins, PpSP15 from Phlebotomus papatasi and PsSP9 fro...

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Bibliographic Details
Main Authors: Mahya Sadat Lajevardi, Tahereh Taheri, Elham Gholami, Negar Seyed, Sima Rafati
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Parasites & Vectors
Subjects:
Protein structural homology
Sand fly
Salivary proteins
Vaccine
Cutaneous leishmaniasis
Online Access:https://doi.org/10.1186/s13071-022-05437-x

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